One tricyclic, imipramine, is primarily metabolized to a demethylated active metabolite, desipramine. Unable to load your collection due to an error Chem Biol Interact. Such was the case with imipramine, but the bioavailability of nortriptyline was not increased. One tricyclic, imipramine, is primarily metabolized to a demethylated active metabolite, desipramine.
2002;41(12):913-58. doi: 10.2165/00003088-200241120-00002.Clin Pharmacokinet. Cimetidine-imipramine interaction: case report and comments. One tricyclic, imipramine, is primarily metabolized to a demethylated active metabolite, desipramine. Ranitidine did not produce any significant changes in either study. 1993 Apr;24(4):301-18. doi: 10.2165/00003088-199324040-00004.Clin Pharmacokinet. 8.Hetzel DJ, Bochner F, Hallpike JF, Shearman DJ, Hann CS.
Thus it is not possible to predict which subjects might develop evidence of toxicity to tricyclics when cimetidine is added to the treatment program.
doctor or pharmacist) for more information.When these two medicines are taken together, cimetidine may prevent your body from processing your antidepressant medicine properly.Your blood levels of antidepressant may rise and cause an increase in the beneficial and toxic effects of the medicine.If you experience weakness, tiredness, dizziness, irregular heartbeat, confusion, anxiety, nervousness, difficulty sleeping, or problems urinating, contact your doctor. Do not start, stop, or change the dosage of any medicine before checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. The degree of change in these kinetic variables varied widely between individuals. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Ann Intern Med 1981 Aug;95(2):244-5. 2012 Apr;10(2):139-50. doi: 10.1016/j.amjopharm.2012.01.001.
Decreased clearance of phenytoin with cimetidine.
Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.Moderate. The interaction between cimetidine and two tricyclic antidepressants was examined in healthy subjects. Cimetidine interaction with imipramine and nortriptyline. Peak nifedipine levels were significantly increased only in the chronic dose study compared to placebo. Am J Psychiatry 1984 Jan;141(1):152-3. This information is generalized and not intended as specific medical advice. Please enable it to take advantage of the complete set of features!
Name must be less than 100 characters Famotidine, an H2-receptor antagonist with a thiazole nucleus, is approximately 7.5 times more potent than ranitidine and 20 times more potent than cimetidin … 1983 Feb;140(2):212-4. doi: 10.1176/ajp.140.2.212.Am J Geriatr Pharmacother.
It's a type of medication called a tricyclic antidepressant (TCA). It was assumed that pretreatment with cimetidine, because of its inhibition of metabolic pathways of both demethylation and hydroxylation as well as its ability to reduce hepatic extraction of these drugs, would increase bioavailability and decrease clearance of both drugs. Further, the bioavailability of the 10-hydroxy metabolite of nortriptyline was increased rather than decreased. Contact your healthcare professional (e.g. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. The other, nortriptyline, is largely metabolized to a 10-hydroxylated metabolite. Imipramine oral tablet is a prescription drug that's used to treat depression and enuresis (bed-wetting).
The monitoring of tricyclic plasma concentrations is probably desirable in such circumstances. Full text Full text is available as a scanned copy of the original print version. The interaction between cimetidine and two tricyclic antidepressants was examined in healthy subjects.
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