Possible side effects 5. The amount absorbed is in linear proportion to the size of the dose.Intravenous infusion: When 75mg diclofenac is administered as an intravenous infusion over 2 hours, mean peak plasma concentrations are about 1.875 ± 0.436µg/ml (1.9µg/mL ≡ 5.9µmol/L). They generally have more serious consequences in the elderly. As fluid retention and oedema have been reported in association with NSAIDs therapy, including diclofenac, particular caution is called for in patients with impaired cardiac or renal function, history of hypertension, the elderly, patients receiving concomitant treatment with diuretics or medicinal products that can significantly impact renal function, and those patients with substantial extracellular volume depletion from any cause, e.g. Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy periodically thereafter, particularly for diuretics and ACE inhibitors due to the increased risk of nephrotoxicity. 0000006798 00000 n The remainder of the dose is eliminated as metabolites through the bile in the faeces. Always read the label / leaflet. Voltarol Rapid tablets contain the potassium salt of diclofenac, a nonsteroidal compound with pronounced and clinically demonstrable analgesic, anti-inflammatory and anti-pyretic properties. The absolute risk for cardiovascular malformation was increased from less than 1% up to approximately 1.5%. No specific studies have been carried out in patients with renal impairment, therefore, no specific dose adjustment recommendations can be made. Inhibition of prostaglandin synthesis may adversely affect the pregnancy and/or the embryo/foetal development. For relief of pain and inflammation. • Like other non-steroidal anti-inflammatory drugs (NSAIDs), diclofenac is also contraindicated in patients in whom attacks of asthma, angioedema, urticaria or acute rhinitis are precipitated by ibuprofen, acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs. Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug used to treat pain and inflammatory diseases such as gout. 0000018627 00000 n Caution is advised when administering diclofenac to patients with mild to moderate renal impairment (see section 4.4 Special warnings and precautions for use). Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. 4.5 Interaction with other medicinal products and other forms of interaction Since systemic absorption of diclofenac during labelled use of the medicated plasters is very low, the risk of developing clinically relevant drug-drug interactions is negligible. Patients appear to be at the highest risk of these reactions early in the course of therapy: the onset of the reaction occurring in the majority of cases within the first month of treatment. In women who may have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of diclofenac should be considered. In particular it is recommended that the lowest effective dosage be used in frail elderly patients or those with a low body weight (see also precautions) and the patient should be monitored for GI bleeding during NSAID therapy.Diclofenac is contraindicated in patients with established congestive heart failure (NYHA II-IV), ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease (see section 4.3 Contraindications).Patients with congestive heart failure (NYHA-I) or significant risk factors for cardiovascular disease should be treated with diclofenac only after careful consideration. Renal colic: One 75mg ampoule intramuscularly. The biotransformation of diclofenac involves partly glucuronidation of the intact molecule but mainly single and multiple hydroxylation followed by glucuronidation. 0000068892 00000 n Other measures may be indicated by the patients clinical condition.Voltarol is a nonsteroidal agent with marked analgesic/anti- inflammatory properties. This is in contrast to the rapid decline in plasma concentrations seen after peak levels have been achieved with oral, rectal or i.m. As with other NSAIDs, the use of diclofenac may impair female fertility and is not recommended in women attempting to conceive. www.ismp.org ISMP’s List of ConfusedDrug Names his list of confused drug names, which includes look-alike and sound-alike name pairs, consists of those name pairs that have been published in the ISMP Medication Safety Alert!® and the ISMP Medication Safety Alert!® Community/Ambulatory Care Edition. • History of haemorrhagic diathesis, a history of confirmed or suspected cerebrovascular bleeding. Voltarol is a nonsteroidal agent with marked analgesic/anti- inflammatory properties. Therefore, the combination should be administered with caution and patients, especially the elderly, should have their blood pressure periodically monitored. Within one hour of ingestion of a potentially toxic amount, activated charcoal should be considered. By continuing to browse the site you are agreeing to our policy on the use of cookies. Diclofenac sodium After administration of 75mg diclofenac by intramuscular injection, absorption sets in immediately, and mean peak plasma concentrations of about 2.558 ± 0.968µg/ml (2.5µg/mL ≡ 8µmol/L) are reached after about 20 minutes.

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