Because the hypotensive effect of perindopril is achieved through vasodilation and effective hypovolemia, it is reasonable to treat perindopril overdose by infusion of normal saline solution.Perindopril erbumine is a white, crystalline powder with a molecular weight of 368.47 (free acid) or 441.61 (salt form). Patients should be followed closely for the first two weeks of treatment and whenever the dose of ACEON® Tablets and/or diuretic is increased. Perindopril erbumine is a white, crystalline powder with a molecular weight of 368.47 (free acid) or 441.61 (salt form). Aceon has been associated with hypotension in 0.3% of uncomplicated hypertensive patients in U.S. placebo-controlled trials. The bioavailability of the drug is about 67%.Perindopril binds slightly to plasma proteins — less than 30%. Symptoms related to orthostatic hypotension were reported in another 0.8% of patients.Symptomatic hypotension is most likely to occur in patients who have been volume or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea or vomiting ACE inhibitors may cause excessive hypotension, and may be associated with oliguria or azotemia, and rarely with acute renal failure and death. Drink plenty of liquids while you are taking perindopril.Your blood pressure will need to be checked often. Dehydration, electrolyte imbalance and hypotension should be treated by established procedures.Among the reported cases of perindopril overdosage, patients who were known to have ingested a dose of 80 mg to 120 mg required assisted ventilation and circulatory support. (See When pregnancy is detected, discontinue Aceon as soon as possible. However, of the reported cases of perindopril overdosage, one (dosage unknown) required assisted ventilation and the other developed hypothermia, circulatory arrest and died following ingestion of up to 180 mg of perindopril. The data presented here are based on results from the 1,417 Aceon-treated patients who participated in the U.S. clinical trials. Perindopril has been studied in relatively few black patients, usually a low-renin population, and the average response of diastolic blood pressure to perindopril was about half the response seen in nonblacks, a finding consistent with previous experience of other ACE inhibitors. Prematurity, intrauterine growth retardation and patent ductus arteriosus have also been reported, although it is not clear whether these occurrences were due to the ACE-inhibitor exposure. Your kidney or liver function may also need to be checked.If you need surgery, tell the surgeon ahead of time that you are using perindopril.If you are being treated for high blood pressure, keep using this medication even if you feel well.

We comply with the HONcode standard for trustworthy health information - The clearance of perindoprilat and its metabolites is almost exclusively renal. In elderly patients (>70 yrs), ACEON® Tablets should be given as a 2 mg dose once daily in the first week, followed by 4 mg once daily in the second week and 8 mg once daily for maintenance dose if tolerated. These include the active ACE inhibitor, perindoprilat (hydrolyzed perindopril), perindopril and perindoprilat glucuronides, dehydrated perindopril and the diastereoisomers of dehydrated perindoprilat. The study examined the long-term effects of perindopril on time to first event of cardiovascular mortality, nonfatal myocardial The 8 mg and 16 mg doses were indistinguishable, and both had a greater effect than the 4 mg dose. If excessive hypotension occurs, the patient should be placed immediately in a supine position and, if necessary, treated with an intravenous infusion of physiological saline. In patients with ischemic heart disease or cerebrovascular disease, an excessive fall in blood pressure could result in a myocardial infarction or a cerebrovascular accident.In patients at risk of excessive hypotension, Aceon therapy should be started under very close medical supervision. It is also worth monitoring how the kidneys work.Keep the product out of the reach of children, in a dry place.

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