The drug is practically insoluble in water and in ether; slightly soluble in diluted (50%) alcohol and  in chloroform; and freely soluble in pyridine.Digoxin is supplied as 125 mcg (0.125 mg) or 250 mcg (0.25 mg) tablets for oral administration.

For discussion of serum digoxin concentrations, see DOSAGE AND ADMINISTRATION section.Due to the considerable variability of these interactions, the dosage of digoxin should be individualized when patients receive these medications concurrently. Eine Studie aus dem Jahr 2013 mit 2.891 Patienten aus den USA zeigte, dass Patienten mit Herzinsuffizienz, die mit Digoxin therapiert wurden, eine um 72% höhere Total loading dose: Administer one-half the total loading dose initially (all formulations), then give one-fourth the total loading dose every 6 to 8 hours for two doses (IV and tablets), or give additional fractions every 4 to 8 hours (oral solution).-Premature: … At delivery, the serum digoxin concentration in the newborn is similar to the serum concentration in the mother. 7Dosierung Die Erhaltungsdosisvon Digoxin beträgt 0,2 - 0,4 mg/Tag. On the other hand, hypocalcemia can nullify the effects of digoxin in humans; thus, digoxin may be ineffective until serum calcium is restored to normal. Although inactivation of these bacteria by antibiotics is rapid, the serum digoxin concentration will rise at a rate consistent with the elimination half-life of digoxin. Bitte logge Dich ein, um diesen Artikel zu bearbeiten. At randomization, 67% were NYHA class I or II, 71% had heart failure of ischemic etiology, 44% had been receiving digoxin, and most were receiving concomitant ACE inhibitor (94%) and diuretic (82%). In high doses, digoxin increases sympathetic outflow from the central nervous system (CNS). The Cockcroft and Gault formula for estimation of creatinine clearance includes age, body weight, and gender. Overall all-cause mortality was 35% with no difference between groups (95% confidence limits for relative risk of 0.91 to 1.07). As a result, certain antibiotics may increase the absorption of digoxin in such patients. These patients had been stable on digoxin, and were randomized to digoxin or placebo. Klicke hier, um einen neuen Artikel im DocCheck Flexikon anzulegen.Freeman JV, Yang J, Sung SH, Hlatky MA, Go AS. Effectiveness and safety of digoxin among contemporary adults with incident systolic heart failure. As per ACCF/AHA guidelines, a loading dose to initiate digoxin therapy in patients with heart failure is not necessary. Inhibition of the enzyme leads to an increase in the intracellular concentration of sodium and thus (by stimulation of sodium-calcium exchange) an increase in the intracellular concentration of calcium.

On a once-daily dosing schedule, the concentration of digoxin will be 10% to 25% lower when sampled at 24 versus 8 hours, depending upon the patient’s renal function. These interactions are related to the fact that digoxin affects contractility and excitability of the heart in a manner similar to that of calcium.Patients receiving digoxin should have their serum electrolytes and renal function (serum creatinine concentrations) assessed periodically; the frequency of assessments will depend on the clinical setting. Wieviel von Digoxin und wie oft sollte Digoxin angewendet werden? These recommendations assume the presence of normal renal function:In children with renal disease, digoxin must be carefully titrated based upon clinical response.Digoxin Tablets, USP, 125 mcg (0.125 mg), Scored I.D.
The usual amount of Digoxin Tablets that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 750 to 1250 mcg (0.75 to 1.25 mg).Digoxin Injection is frequently used to achieve rapid digitalization, with conversion to Digoxin Tablets or digoxin solution in capsules for maintenance therapy. The median daily dose prescribed was 0.25 mg. Additional doses of 125 to 375 mcg (0.125 to 0.375 mg) may be given cautiously at 6 to 8-hour intervals until clinical evidence of an adequate effect is noted. However, when the primary manifestation of digoxin overdosage is a cardiac arrhythmia, additional therapy may be needed.If the rhythm disturbance is a symptomatic bradyarrhythmia or heart block, consideration should be given to the reversal of toxicity with DIGIBINDIf the rhythm disturbance is a ventricular arrhythmia, consideration should be given to the correction of electrolyte disorders, particularly if hypokalemia (see Administration of Potassium subsection) or hypomagnesemia is present. Select one or more newsletters to continue. DIGIBIND is a specific antidote for digoxin and may be used to reverse potentially life-threatening ventricular arrhythmias due to digoxin overdosage.DIGIBIND should be used to reverse the toxic effects of ingestion of a massive overdose. The trend was evident in subgroups of patients with mild heart failure as well as more severe disease, as shown in Table 3. Digoxin hat eine geringe therapeutische Breite. These adverse experiences are consistent with results from a large, placebo-controlled mortality trial (DIG trial) wherein over half the patients were not receiving digoxin prior to enrollment.Withdrawal of digoxin may be all that is required to treat the adverse reaction.

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