If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. Follow your doctor's orders or the directions on the label. Tell patients to inform their physician if they feel lightheaded or faint.
Thiazides may cause intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism. DOSAGE FORMS, COMPOSITION AND PACKAGING 23 PART II: SCIENTIFIC INFORMATION PHARMACEUTICAL INFORMATION 25 CLINICAL TRIALS 25 DETAILED PHARMACOLOGY 29 TOXICOLOGY 29 REFERENCES 35 PART III: CONSUMER INFORMATION 36 . Children younger than 6 years of age—Use and dose must be determined by your doctor. Adverse events have been limited to those that were reported previously with irbesartan or hydrochlorothiazide (HCTZ). These highlights do not include all the information needed to use Irbesartan and Hydrochlorothiazide safely and effectively. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.If oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion. Usual dose: 25 mg to 100 mg orally once or twice daily Comments:-Some patients respond to intermittent therapy, (i.e., administration on alternate days or on 3 to 5 days each week). Find patient medical information for Irbesartan-Hydrochlorothiazide Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The overall incidence of adverse events was similar with the combination and placebo. This incidence was significantly less (p=0.023) than the 6.8% of patients treated with placebo who discontinued therapy.In these double-blind controlled clinical trials, the following adverse events reported with AVALIDE occurred in ≥1% of patients, and more often on the irbesartan-hydrochlorothiazide combination than on placebo, regardless of drug relationship:The following adverse events were also reported at a rate of 1% or greater, but were as, or more, common in the placebo group: headache, sinus abnormality, cough, URI, pharyngitis, diarrhea, rhinitis, urinary tract infection, rash, anxiety/nervousness, and muscle cramp.Adverse events occurred at about the same rates in men and women, older and younger patients, and black and non-black patients.Adverse events in Studies V and VI were similar to those described above in Studies I through IV.Other adverse events that have been reported with irbesartan, without regard to causality, are listed below:Other adverse events that have been reported with hydrochlorothiazide, without regard to causality, are listed below:In the moderate hypertension Study V (mean SeDBP between 90 and 110 mmHg), the types and incidences of adverse events reported for patients treated with AVALIDE were similar to the adverse event profile in patients on initial irbesartan or HCTZ monotherapy.
Untreated acute angle-closure glaucoma can lead to permanent vision loss. No gender-related dosage adjustment is necessary.In elderly subjects (age 65 to 80 years), irbesartan elimination half-life was not significantly altered, but AUC and CIn healthy black subjects, irbesartan AUC values were approximately 25% greater than whites; there were no differences in CThe pharmacokinetics of irbesartan were not altered in patients with renal impairment or in patients on hemodialysis. In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so irbesartan and hydrochlorothiazide is not recommended.No dosage adjustment is necessary in patients with hepatic impairment.In patients not controlled on monotherapy with irbesartan or hydrochlorothiazide, the recommended doses of irbesartan and hydrochlorothiazide, in order of increasing mean effect, are (irbesartan-hydrochlorothiazide) 150/12.5 mg, 300/12.5 mg, and 300/25 mg. The oral LDIrbesartan and hydrochlorothiazide tablets are a combination of an angiotensin II receptor antagonist (ATIrbesartan is a non-peptide compound, chemically described as a 2-butyl-3-[Irbesartan is a white to off-white crystalline powder with a molecular weight of 428.5.
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