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Are leaner times ahead?, Pharmacotherapy in obesity: a systematic review and meta-analysis of randomized controlled trials of anti-obesity drugs, Ten-year Medicare budget impact of increased coverage for anti-obesity intervention, Identification and Management of Cardiometabolic Risk after Spinal Cord Injury: Clinical Practice Guideline for Health Care Providers, Centrally Acting Agents for Obesity: Past, Present, and Future, Why Weight? H.M., D.D.K., and E.D. We also thank Victoria Webb for editorial assistance and Sheri Volger for reviewing the manuscript.All academic authors received research grants from Orexigen Therapeutics (to their respective institutions) to conduct the study. The first analysis included all randomized participants (i.e., randomized LOCF; Safety analyses were performed on the safety analysis set. GlaxoSmithKline: Research Triangle Park, NCRational design of a combination medication for the treatment of obesityComparison of combined bupropion and naltrexone therapy for obesity with monotherapy and placeboThe arcuate nucleus as a conduit for diverse signals relevant to energy homeostasisLeptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleusThe need to feed: homeostatic and hedonic control of eatingBupropion SR vs. placebo for weight loss in obese patients with depressive symptomsNational Institutes of Health/National Heart, Lung, and Blood InstituteClinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults—the Evidence ReportRandomized trial of lifestyle modification and pharmacotherapy for obesityComparison of methods for delivering a lifestyle modification program for obese patients: a randomized trialReduction in the incidence of type 2 diabetes with lifestyle intervention or metforminNational Heart, Lung, and Blood Institute & North American Association for the Study of ObesityThe Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in AdultsDevelopment of a brief measure to assess quality of life in obesityDevelopment and validation of the food‐craving inventoryAn open‐label study of naltrexone and bupropion combination therapy for smoking cessation in overweight and obese subjectsThe Inventory of Depressive Symptomatology (IDS): clinician (IDS‐C) and self‐report (IDS‐SR) ratings of depressive symptomsBupropion SR enhances weight loss: a 48‐week double‐blind, placebo‐ controlled trialOne‐year health‐related quality of life outcomes in weight loss trial participants: comparison of three measuresPlacebo‐psychotherapy combinations: inappropriate representations of psychotherapy in drug‐psychotherapy comparative trialsAttrition from randomized controlled trials of pharmacological weight loss agents: a systematic review and analysisBenefits of lifestyle modification in the pharmacologic treatment of obesity: a randomized trialLong-Term Current Management of Enduring Obesity in Diabetes, Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery, Medications for the treatment of obesity in adolescents, Therapeutic Advances in Endocrinology and Metabolism, Cardiometabolic Disease and Dysfunction Following Spinal Cord Injury, Physical Medicine and Rehabilitation Clinics of North America, Integration of 2D Materials with Nitrides for Novel Electronic and Optoelectronic Applications,

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