For example, tyramine, a component of cheese and a potent vasoconstrictor, can cause hypertensive crisis in some patients who take monoamine oxidase inhibitors and eat cheese.
2010 Antibiotics save lives, but any time antibiotics are used, they can cause side effects and lead to antibiotic resistance. Each year in the U.S., at least 2.8 million people get an antibiotic-resistant infection, and more than 35,000 people die. Our chart lets you know which medicines are safe to take while breastfeeding and which are important to avoid. and formulary information changes. informational and educational purposes only. Brought to you by Controlled studies in pregnant women show no evidence of fetal risk.Binds to penicillin-binding proteins and inhibits final transpeptidation step of peptidoglycan synthesis, resulting in cell-wall death; resists degradation by beta-lactamase; proper dosing and appropriate route of administration are determined by condition of patient, severity of infection, and susceptibility of microorganismPeak serum time: 2-3 hr (PO); 15-60 min (IM); 2-3 min (IV)Widely distributed to body tissues and fluids, including cerebrospinal fluid (CSF)Half-life: 1-2 hr (prolonged with renal impairment)Additive: Aminoglycosides, ciprofloxacin, ranitidine, sodium bicarbonateY-site: Azithromycin, cisatracurium (potentially; compatible at low concentration [0.1 mg/mL]), clarithromycin, filgrastim, fluconazole, midazolam, vancomycin, vinorelbineAdditive: Clindamycin, floxacillin, furosemide, gentamicin (incompatible in total parenteral nutrition [TPN]), metronidazole, midazolam, netilmicinY-site (partial list): Acyclovir, allopurinol, amiodarone, diltiazem, linezolid, milrinone, morphine sulfate, ondansetron, propofol, tacrolimusDirect injection: reconstitute in 8 mL (for 750-mg vial) or 16 mL (for 1.5-g vial) to obtain ~90 mg/mL solutionInfusion: Reconstitute in 100 mL SWI, D5W or NS to obtain 7.5 mg/mL (750-mg vial) or 15 mg/mL (1.5-g vial) solution7.5 g bulk package not to be used for direct injectionReconstitute 750 mg in 3 mL SWI to obtain ~220 mg/mL solutionDirect injection: Inject directly into vein over 3-5 minutes or slowly into tubing of free-flowing compatible IV solutionAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Antibiotic Awareness Week and throughout the year, CDC promotes Be Antibiotics Aware, an educational effort to raise awareness about the importance of safe antibiotic prescribing and use.
Contact the applicable plan In U.S. doctors’ offices and emergency departments, at least 47 million antibiotic prescriptions each year are unnecessary, which makes improving antibiotic prescribing and use a national priority.
1821504-overview CDC twenty four seven. This 2018 update highlights new antibiotic stewardship data, programs, and resources since the July 2017 report. 2002 Nutritional deficiencies can affect drug absorption and metabolism. 2000356-overview Cordarone (amiodarone): Patients taking Zocor (Simvastatin) in doses higher than 20 mg while also taking Cordarone run the risk of developing a rare condition of muscle injury called rhabdomyolysis, which can lead to kidney failure or death. Saving Lives, Protecting People If you or a loved one have experienced a mistake with a medication or have a safety concern to share with others, we would like to hear from you.
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500-750 mg IV q8hr; switch to oral therapy as soon as clinically possible750 mg IV/IM q8hr; switch to oral therapy as soon as clinically possible750 mg IV/IM q8hr; switch to oral therapy as soon as clinically possibleUncomplicated: 1 g PO once or 1.5 g IM once at 2 different sites with 1 g probenecid PO1.5 g IV/IM q8hr; may be administered q6hr in life-threatening situations3 months-12 years: 30 mg/kg/day suspension PO divided q12hr for 10 days; not to exceed 1000 mg/day; alternatively, 75-150 mg/kg/day IV/IM divided q8hr; not to exceed 6 g/day 3 months-12 years: 30 mg/kg/day suspension PO divided q12hr for 10 days; not to exceed 1000 mg/day; alternatively, 75-150 mg/kg/day IV/IM divided q8hr; not to exceed 6 g/day 3 months-12 years: 30 mg/kg/day suspension PO divided q12hr for 10 days; not to exceed 1000 mg/day or 75-100mg/kg/day IV/IM divided q8hr; not to exceed 6 g/day 3 months-12 years: 20 mg/kg/day PO divided q12hr for 10 days; not to exceed 500 mg/day or 75-150 mg/kg/day IV/IM divided q8hr; not to exceed 6 g/day Increase in blood urea nitrogen (BUN) and creatinineProlonged prothrombin time (PT)/international normalized ratio (INR)Prolonged INR in nutritionally deficient patients, prolonged treatment, and hepatic and renal disease reportedFilm-coated tablet and oral solution are not bioequivalent; tablets should not be crushedUse caution in patients with history of colitis, renal impairment, or with a history of seizure disordersUse with caution in patients with history of penicillin allergyReduce dosage by 50% if CrCl is 10-30 mL/min and by 75% if CrCl <10 mL/min (high doses may cause CNS toxicity)Bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapyAvailable data from published epidemiologic studies, case series, and case reports over several decades in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomesBased on several published case reports describing multiple lactating women receiving therapy via intravenous, intramuscular, and oral routes, drug is present in human milk; the highest maternal milk concentration described occurred in lactating women 8 hours after an intramuscular administration of 750 mg; allowing for an infant milk consumption of 150 mL/kg/day, the estimated breastfed infant dose would be less than 1% of adult doseNo data are available on effects of drug on breastfed infant or on milk production; developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal conditionA: Generally acceptable.
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