Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Intravenous Cyclophosphamide and Plasmapheresis in Dialysis-Dependent ANCA-Associated VasculitisIntravenous Cyclophosphamide and Plasmapheresis in Dialysis-Dependent ANCA-Associated VasculitisWegener’s granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years.Wegener granulomatosis: An analysis of 158 patients.Early mortality in systemic vasculitis: Relative contribution of adverse events and active vasculitis.Relapse rate, renal survival, and cancer morbidity in patients with Wegener’s granulomatosis or microscopic polyangiitis with renal involvement.Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis.Incidence and predictors of urotoxic adverse events in cyclophosphamide-treated patients with systemic necrotizing vasculitides.Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-associated vasculitis: Follow-up data from European Vasculitis Study Group clinical trials.The value of pulse cyclophosphamide in ANCA-associated vasculitis: Meta-analysis and critical reviewPulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial.Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: Long-term follow-up.ANCA-associated renal vasculitis at the end of the twentieth century—a disease of older patients.Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis.Chances of renal recovery for dialysis-dependent ANCA-associated glomerulonephritis.Outcome of ANCA-associated renal vasculitis: A 5-year retrospective study.Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis.Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: Comparison of two independent cohorts.The epidemiology of primary systemic vasculitides involving small vessels in Crete (southern Greece): A comparison of older versus younger adult patients.ANCA-associated glomerulonephritis in the very elderly.Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis.Rituximab versus cyclophosphamide for ANCA-associated vasculitis.Clinical Journal of the American Society of NephrologyPerformance of the Kidney Failure Risk Equation by Disease Etiology in Advanced CKDIgE-Mediated Immune Response and Antibody-Mediated RejectionChanges in Blood Pressure and Arterial Hemodynamics following Living Kidney DonationCOVID-19 Outbreak and Management Approach for Families with Children on Long-Term Kidney Replacement TherapyThe Electronic Medical Record and Nephrology Fellowship Education in the United StatesTrends and Outcomes with Kidney Failure from Antineoplastic Treatments and Urinary Tract Cancer in France The doses below can be regarded as general guidelines: IV:-When used alone, the initial dose for patients with no hematologic deficiency is 40 to 50 mg/kg IV in divided doses over 2 to 5 days-Alternative dose: 10 to 15 mg/kg IV every 7 to 10 days OR 3 to 5 mg/kg IV 2 times a week Time on hemodialysis was recorded, as well as time to return to hemodialysis in those patients who initially regained independent renal function but then progressed to end stage renal failure.The MEPEX study was a multinational randomized controlled study that recruited patients with serum creatinine >500 μmol/L (5.7 mg/dl) between 1995 and 2004 and utilized oral cyclophosphamide (at 2 mg/kg) and similar regimens for steroids and plasmapheresis.
All patients with AAV and severe renal disease who presented between 2005 (2006 for the Hammersmith cohort) and 2010 and required renal replacement therapy during their disease presentation were included. Select one or more newsletters to continue. Cyclophosphamide (CYP) has long been part of the treatment regimen in patients presenting with ANCA-associated vasculitis (AAV), providing benefits with respect to both renal and patient survival (1,2).However, its use is associated with significant adverse events and it has a dose-dependent toxicity. Estimated GFR (eGFR) was calculated using the abbreviated Modified Diet in Renal Disease (MDRD) study equation. Within this group, infections were common, with five patients developing infectious complications and another developing severe leukopenia after the first dose of CYP.We obtained detailed follow-up data on the patients in the MEPEX study. This was treated with a change in immunosuppression from MMF to oral cyclophosphamide for 3 months. Prednisolone was commenced at a dose of 1 mg/kg (maximum 60 kg) with a weekly decrease in dose for the first 3 weeks, followed by a more gradual decrease aiming for 12.5 mg by 3 months, 10 mg by end of month 5, and 7.5 mg by 12 months. Cyclophosphamide is one of a number of medications first developed as a chemotherapy drug (a medication used in the treatment of cancer).
Of these eight, three patients either presented dialysis dependent and never regained function, or returned to dialysis within 30 days. Ondansetron 5mg/m2 IV (Max 8mg) prior to Cyclophosphamide infusion (Metoclopramide 100micrograms/kg (Max 10mg) tds prn for 3 days for persistent nausea). There were four additional deaths after 24 months.This retrospective analysis demonstrates a high rate of renal recovery in patients with AAV and renal involvement requiring dialysis who were treated with pulsed CYP and adjunctive plasmapheresis. We comply with the HONcode standard for trustworthy health information - 6. All patients required hemodialysis during their initial presentation.
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