Consequently, the patients with cancer enrolled in the study were much healthier and had much lower mortality than those enrolled in the CLOT trial (6% and 7.7% at 3 months for apixaban and enoxaparin/warfarin in the AMPLIFY trial vs 39% and 41% at 6 months for dalteparin and oral anticoagulant in the CLOT trial, respectively). The safety and efficacy of warfarin is critically dependent on maintaining the INR within Seek specialist input if any abnormalities. x��=�r7���?��Z����V�U�f�Ml��Tꔳ5�t"� endobj This guideline outlines a standardised approach for: '̼ݿ>0�8ژ�����5�v���p�uzJ�/�,�Y�j��"hT&��L�R�����7�D�B�yD�����Nr�BzJ����7�[�WQ�=�2�B:�vzR�W��;U ;����f����-�����-tە���ج�r�Lci�����SX�����W7~�5�e+�����������R����i���������7������S� ��E endstream endobj 1765 0 obj <>stream �H�s�nn�hֶ�,G�{�p�eR&06�{�ʭg�gpk[�O&;S6Lp�*?��A��h�)b�Ofo����Eq�&�����έ���Y�0�f㪒 ��ܒ�! *h�,��D�D�D�"g5"g�nQbQbV�RY�����Zlg` �!#s endobj %PDF-1.5 <>>> ESC Clinical Practice Guidelines aim to present all the relevant evidence to help physicians weigh the benefits and risks of a particular diagnostic or therapeutic procedure on Atrial Fibrillation. 1�PF <> 1 0 obj 3 0 obj 1762 0 obj <>stream h�24�0R0P���w�/�+Q0����L)�64�0�)�Ic0i L>����{Բ����� ��9E����8��%�Z��H� �F8P+A�ul(f"� 6�i��V� Ԍ� �$Ȕt�^���T�b��k���+h۔+Ŭ��}��P-���z�6�糷��Ѝ�ySN�(�"}��]�ҧ�-�3�M洢�U�d�i�P�g��gڀA;i��P���}��~�¨����h� The effect of warfarin is measured by a blood test referred to as INR (international normalised ratio). INR is a measure of how much longer it takes the blood to clot when oral anticoagulation is used. chair), for the CCS Atrial Fibrillation Guidelines Committee* * For a complete listing of the primary and secondary members of the CCS Atrial Fibrillation Guidelines Committee along with their affiliations, see the end of this document. 4 0 obj the setting of over anticoagulation, is a major concern. 2 0 obj endstream endobj 1764 0 obj <>stream <>
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Clinical Excellence Commission December 2018 INTRODUCTION This clinical guideline is intended to assist clinicians with the inpatient and outpatient management of adult patients (over 16 years of age) undergoing procedures* who are taking anticoagulant or antiplatelet therapy. %PDF-1.6 %���� This summary lists all recommendations presently in force. h�24�0V0P���w,-��/��M,��/���K�����w.JM,���sI,I�p�220�002�045221�����f&�秕�S�OK�LNU�/JQ0200����OA�4064240131�(�O)MN�o��@� �3� <>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 21 0 R] /MediaBox[ 0 0 596.04 842.04] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> endobj %���� Introduction Warfarin has a narrow therapeutic index and regular titration of the dose against the anticoagulant effect in the blood, as assessed by the INR, is essential.
The INR is checked on day 3 and 4 and the warfarin dose is … Before initiating warfarin anticoagulation request the following baseline investigations liver function tests full blood count clotting screen.
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