What is sildenafil available as?
Sometimes babies on ventilators need it in the neonatal unit. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2020 Aug 15;7(8):E97.
2016 Nov;102:21-24. doi: 10.1016/j.earlhumdev.2016.09.009.
Epub 2015 May 28.Early Hum Dev.
Kaplan-Meier curve demonstrates overall survival, and compares the survival of WHO Group 1 PH (IPAH, CHD and CTD) and Group 3 PH (BPD and CDH).
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Kaplan-Meier curve demonstrates overall survival,… Kaplan-Meier curve demonstrates overall survival, and compares the survival of WHO Group 1… Pulmonary hypertension means high blood pressure in the lungs, which often occurs after heart surgery.
2016 Nov;102:21-24. doi: 10.1016/j.earlhumdev.2016.09.009. A total of 33 pediatric patients with PAH were retrospectively evaluated.
In 2012, the United States Food and Drug Administration (USFDA) issued a warning regarding the of use high-dose sildenafil in children with PAH.
Sildenafil is one of the therapeutic agents used extensively in the treatment of PAH in children, as an off-label drug.
The primary efficacy data suggest that sildenafil is beneficial for facilitating the weaning of inhaled nitric oxide in children after cardiac surgery.
Epub 2016 Sep 21.Clavé MM, Maeda NY, Thomaz AM, Bydlowski SP, Lopes AA.Congenit Heart Dis.
2013 Mar 15;187(6):572-5. doi: 10.1164/rccm.201210-1928PP.
Epub 2013 Apr 26.Nees SN, Rosenzweig EB, Cohen JL, Valencia Villeda GA, Krishnan US.Children (Basel).
RESULTS: There were 269 children included in this study: 47 with idiopathicpulmonary arterial hypertension, 53 with congenital heart disease, 135 withbronchopulmonary dysplasia, 24 with congenital diaphragmatic hernia, and 7 withother causes. Please enable it to take advantage of the complete set of features! 2 On the basis of in part the promising early findings of SUPER-1, … Unable to load your collection due to an error
2015 Nov 1;37(11):2598-2607.e1.
2015). Epub 2019 Jul 9.Dardi F, Manes A, Palazzini M, Bachetti C, Mazzanti G, Rinaldi A, Albini A, Gotti E, Monti E, Bacchi Reggiani ML, Galiè N.Eur Respir J. Free PMC article Name must be less than 100 characters Sildenafil for the Treatment of Pulmonary Hypertension in Children - PubMed Pulmonary hypertension, including pulmonary arterial hypertension (PAH), is a serious disease in children, but few clinical studies have been conducted to evaluate treatment regimens in this population. 2017 Jul;10(7):e000026.
Epub 2014 Sep 16.Early Hum Dev. Although PAH has no curative treatment, a greater understanding of pathophysiology, technological advances resulting in early diagnosis, and the availability of several newer drugs have improved the outlook for patients with PAH. This has led to a peculiar situation where there is a paucity of approved therapies for the management of PAH in children and the use of the most extensively used drug being discouraged by the regulator. 2019 Apr 5;132(7):811-818. doi: 10.1097/CM9.0000000000000145.
2017 Dec;38(8):1703-1708. doi: 10.1007/s00246-017-1716-4.
Survival was worse in Group 3 PH vs. Group 1 PH (p=0.02).
Case series and small studies, as well as the first large randomized controlled trial, have demonstrated the safety and efficacy of sildenafil in improving mean pulmonary artery pressure, pulmonary vascular resistance, cardiac index, and exercise tolerance in pulmonary arterial hypertension.
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