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Search for other works by this author on: Providers often have difficulty discriminating between serious versus benign rashes, and the package insert recommends discontinuing the medication at the first sign of a rash. In addition, pertinent labs (eg, liver function tests, complete blood count) and vitals were all within normal limits. This is another case that can be added to the literature noting a successful retrial with LTG in a patient whose rash was considered Recipient(s) will receive an email with a link to 'Rechallenge of lamotrigine after development of rash' and will not need an account to access the content.
No adjustments to the initial lamotrigine dosing titration schedule are needed in women starting estrogen-containing contraceptives other than those recommended for initiation of lamotrigine in patients receiving other selected AEDs.

Roughly 1 month later, the rash resurfaced after finishing the course of steroids, and LTG was stopped by the provider. This website uses cookies. Please try after some time.Your message has been successfully sent to your colleague.Some error has occurred while processing your request. Please try after some time.Get new journal Tables of Contents sent right to your email inbox International Clinical Psychopharmacology24(2):105-110, March 2009. 800-638-3030 (within USA), 301-223-2300 (international)Registered users can save articles, searches, and manage email alerts.Your message has been successfully sent to your colleague.Some error has occurred while processing your request.
Bipolar disorder: assessment and management.Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for PsychopharmacologyDelayed Stevens–Johnson syndrome secondary to the use of lamotrigine in bipolar mood disorderCharacterization of drug-specific T cells in lamotrigine hypersensitivityRash in multicenter trials of lamotrigine in mood disordersLamotrigine-associated rash: to rechallenge or not to rechallenge?Stevens-Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative databaseRechallenge with lamotrigine after a rash: a prospective case series and review of the literatureLamotrigine rechallenge after a skin rash. 12 No patients developed SJS or TEN; the 5 unsuccessful cases were due to development of either serious rashes (2 cases), benign rashes (2 cases), or signs of …

Since it had been more than 6 months of being off LTG and he felt this medication worked best, a rechallenge seemed to be an appropriate option. The risks and benefits were weighed, and the pharmacist recommended to restart LTG at a lower dose of 12.5 mg daily and titrate up every 2 weeks as recommended in A case series published in 2010 identified 48 cases of LTG rechallenge and noted a success rate of 87 percent.It does not appear that our case patient exhibited any of the serious symptoms described above except for some facial involvement, so he would have been likely deemed a severity of 1.It is important to examine the risks versus benefits before a rechallenge with LTG as the success rate (ie, absence of rash) can be quite high. Your Email:

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