The primary objective of this prospective, single-centre randomized controlled trial is to assess the efficacy of three different drugs in treatment of ureteral stents related symptoms (Beta 3 adrenergic receptor agonist; Mirabegron 50mg) vs. (Alpha 1 adrenergic receptor antagonist; Tamsulosin 0.4mg) vs. (Anticholinergic; Solifenacin 10 mg) using validated symptoms questionnaires.
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We compared this treatment with solifenacin succinate 5 mg or mirabegron 50 mg alone, and found that … Antimuscarinics and beta-3 adrenoceptor agonist are two different classes of medication for OAB. Epub 2018 Apr 23.Abrams P, Kelleher C, Staskin D, Rechberger T, Kay R, Martina R, Newgreen D, Paireddy A, van Maanen R, Ridder A.Eur Urol. Register Please enable it to take advantage of the complete set of features! Each randomization number will be assigned to individual patient according to the time-sequence for screened patient become eligible.Patients receiving solifenacin and mirabegron might have similar therapeutic effects on decrease of USS, but patients who received mirabegron might have less adverse events such as dry mouth or difficulty in urination. This study tries to compare the safety and therapeutic efficacy between solifenacin …
informed consent was obtained from each patient before the study. 2019 Aug 20;9(8):388. doi: 10.3390/biom9080388.Sui W, Li H, Yang Y, Jing X, Xue F, Cheng J, Dong M, Zhang M, Pan H, Chen Y, Zhang Y, Zhou Q, Shi W, Wang X, Zhang H, Zhang C, Zhang Y, Cao Y.Proc Natl Acad Sci U S A. Beta-3 adrenoceptor agonist (mirabegron) can also decrease DO and improve OAB symptoms. 2014 Jan;33(1):17-30. doi: 10.1002/nau.22505. Gratzke C, van Maanen R, Chapple C, Abrams P, Herschorn S, Robinson D, Ridder A, Stoelzel M, Paireddy A, Yoon SJ, Al-Shukri S, Rechberger T, Mueller ER.Eur Urol. Discontinuation due to side-effects was significantly more frequent in the solifenacin group than the mirabegron group (27.3 vs. 7.9%, P < 0.05). In contrast, discontinuation due to lack of efficacy was significantly more frequent in the mirabegron group than the solifenacin group (36.8 vs. 5.6%, P < 0.05). Improvements in mean adjusted difference in the MVV/micturition for the combined S5 + M50 group vs solifenacin 5 mg and mirabegron 50 mg were 8.75 mL (nominal P = 0.005) and 17.74 mL (nominal P < 0.001), respectively. 2019 Aug;34(8):1615-1625. doi: 10.1007/s11606-019-05028-0.
Unable to load your delegates due to an error Combination therapy was statistically superior to mirabegron and solifenacin for the number of incontinence episodes (vs mirabegron: adjusted mean difference [AMD] -0.5, 95% confidence interval [CI] -0.7 to -0.2, p<0.001; vs solifenacin: AMD -0.1, 95% CI -0.4 to 0.1, p=0.002) and micturitions (vs mirabegron: AMD -0.5, 95% CI -0.8 to -0.2, p<0.001; vs solifenacin: AMD -0.4, 95% CI -0.7 to -0.1, p=0.004). Springer To compare persistence with medication and the reasons for discontinuation of mirabegron or solifenacin therapy up to12 months in women with overactive bladder (OAB).Female OAB patients who presented to women's urology clinics were enrolled in a prospective, randomized, two‐arm study. Epub 2019 Jul 25.Balk EM, Adam GP, Corsi K, Mogul A, Trikalinos TA, Jeppson PC.J Gen Intern Med.
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