For treatment of disseminated infection caused by mycobacterium avium complex (MAC); use in combination with other antimycobacterial drugs (eg, ethambutol) Peptic Ulcer Disease. “An inhibitory effect of lipoic acid on PDKs would result in less phosphorylation of E1 and hence inhibition of PDKs could upregulate the activity of PDC and rectify the balance between the demand and supply of oxygen, which could lead to cancer cell death. In one clinical trial evaluating treatment with clarithromycin on outcomes in patients with coronary artery disease, an increase in risk of all-cause mortality one year or more after the end of treatment was observed in patients randomized to receive clarithromycin.
[see Warnings and Precautions Clarithromycin Dosage Adjustments in Patients with Renal Impairment [see Drug Interactions Controlled studies in pregnant women show no evidence of fetal risk.Semisynthetic macrolide antibiotic that reversibly binds to P site of 50S ribosomal subunit of susceptible organisms and may inhibit RNA-dependent protein synthesis by stimulating dissociation of peptidyl t-RNA from ribosomes, thereby inhibiting bacterial growthHighly stable in presence of gastric acid (unlike erythromycin); food delays but does not affect extent of absorptionPeak plasma time: 2-3 hr (immediate release); 5-8 hr (extended release)Distributed widely into most body tissues except central nervous system (CNS)Half-life: Immediate release, 3-7 hr; active metabolite, 5-9 hrRenal clearance: Approximates normal glomerular filtration rate (GFR)Add half the volume of water to the bottle containing granules and shake vigorously, THENTablet or granules may be administered with or without foodTablets: Store at controlled room temperature of 20-25°C (68-77°F); excursions permitted to 15-30°C (59-86°F)Adding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans.
[see Warnings and Precautions
2012 Dec;47(4):293-297.
No data are available to assess the effects of clarithromycin or 14-OH clarithromycin on milk production.Serum and milk samples were obtained after 3 days of treatment, at steady state, from one published study of 12 lactating women who were taking clarithromycin 250 mg orally twice daily. 1900 M STREET. * All trademark names are the property of their respective owners. Intent-to-Treat Drug(s) that Affect the Pharmacokinetics of Clarithromycin[see Clinical Pharmacology
Drug–drug interaction between colchicine and clarithromycin, resulting in colchicine intoxication, has been noted, mainly in association with gout and pneumonia. Table 20. [See Contraindications
It is soluble in acetone, slightly soluble in methanol, ethanol, and acetonitrile, and practically insoluble in water.Each white to off-white oval film-coated immediate-release clarithromycin tablet, USP contains 250 mg or 500 mg of clarithromycin and the following inactive ingredients: croscarmellose sodium, magnesium stearate, microcrystalline cellulose, povidone, silicon dioxide, hypromellose, titanium dioxide and polyethylene glycol.For specific information regarding susceptibility test interpretive criteria, and associated test methods and quality control standards recognized by FDA for this drug, please see: http://www.fda.gov/STICAll tests had negative results except the
All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Clarithromycin tablets, USP in combination with amoxicillin and PREVACID (lansoprazole) or PRILOSEC (omeprazole) Delayed-Release Capsules, as triple therapy, are indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or five-year history of duodenal ulcer) to eradicate H. pylori. Here,Dr. Table 7.
(41)Another MALT Lymphoma occurs in the orbital lymphoid tissue. See full prescribing information for CLARITHROMYCIN TABLETS. Use: Treatment of patients with Helicobacter pylori infection and duodenal ulcer disease to eradicate H pylori Expression of the activation antigen CD69 on T and B cells was considered evidence of a cellular response to H. pylori. [see Warnings and Precautions
Clinical Studies 500 mg PO q8-12hr for 10-14 days [see Warnings and Precautions Colchicine-clarithromycin-induced rhabdomyolysis in Familial Mediterranean Fever patients under treatment for Helicobacter pylori.
Thus, in patients with duodenal ulcer associated with
Limited data from a small number of published human studies with clarithromycin use during pregnancy are insufficient to inform drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes.
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