Such data are insufficient to indicate either an association or a lack of association between atomoxetine and adverse pregnancy and/or lactation outcomes. Strattera administered once daily demonstrated statistically significantly greater reduction in severity of ADHD symptoms compared with placebo as judged by teachers and parents.In a randomised, double-blind, parallel group, 6 week paediatric study to test the non-inferiority of atomoxetine to a standard extended-release methylphenidate comparator, the comparator was shown to be associated with superior response rates compared to atomoxetine. In the study with co-morbid anxiety, the comorbid condition of anxiety did not deteriorate with atomoxetine treatment.The efficacy of atomoxetine in maintaining symptom response was demonstrated in a study where after an initial active treatment period of 24 weeks, patients who met criteria for clinically meaningful response (as defined by improvement on both CAARS-Inv:SV and CGI-S scores) were randomized to receive atomoxetine or placebo for an additional 6 months of double-blind treatment. Due to the dose limitation imposed by the clinical (or exaggerated pharmacological) response of the animals to the drug combined with metabolic differences among species, maximum tolerated doses in animals used in nonclinical studies produced atomoxetine exposures similar to or slightly above those that are achieved in CYP2D6 poor metabolizing patients at the maximum recommended daily dose.A study was conducted in young rats to evaluate the effects of atomoxetine on growth and neurobehavioral and sexual development. Severe cardiovascular disorders may include severe hypertension, heart failure, arterial occlusive disease, angina, haemodynamically significant congenital heart disease, cardiomyopathies, myocardial infarction, potentially life-threatening arrhythmias and channelopathies (disorders caused by the dysfunction of ion channels). See your doctor.taking a prescription drug.
The proportion of patients relapsing after 1 year was 18.7% and 31.4% (atomoxetine and placebo, respectively). No additional benefit has been demonstrated for doses higher than 1.2 mg/kg/day [see Clinical Studies (14)]. See your doctor.taking a prescription drug.
There was a slight increase in QTc interval with increased atomoxetine concentration.The pharmacokinetics of atomoxetine in children and adolescents are similar to those in adults. Because of the lack of data, atomoxetine should be avoided during breastfeeding.Data on the effects on the ability to drive and use machines are limited. Because of a possible increase in blood pressure, atomoxetine may decrease the effectiveness of antihypertensive drugs / drugs used to treat hypertension. Certain foods or drinks are more likely to cause heartburn, such as rich, spicy, fatty and fried foods, chocolate, caffeine, alcohol and even some fruits and vegetables.
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