; de Miranda, P.; Laskin, O.L. Departments of Medicine, Pediatrics and Microbiology, University of Alabama in Birmingham.Departments of Medicine, Pediatrics and Microbiology, University of Alabama in Birmingham.Departments of Medicine, Pediatrics and Microbiology, University of Alabama in Birmingham.Departments of Medicine, Pediatrics and Microbiology, University of Alabama in Birmingham.Departments of Medicine, Pediatrics and Microbiology, University of Alabama in Birmingham.Departments of Medicine, Pediatrics and Microbiology, University of Alabama in Birmingham.Use the link below to share a full-text version of this article with your friends and colleagues. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. ; Wyborny, C.; Hintz, M. and Keeney, R.E. Proceedings of the National Academy of Science (USA) 74: 5716–5720 (1977).Field, H.J. and DeStefano, E.: Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine.
; Lee, K. and Alexander, F.: Effect of cimetidine on renal function in normal man. : Treatment of cytomegalovirus pneumonia with high-dose acyclovir. ; Laskin, O.L. Therefore, only four parameters were needed to characterize the disposition of acyclovir, namely CL, V … : Acyclovir prophylaxis of herpes simplex virus infections: A trial in bone marrow transplant recipients. and Versteeg, J.: Acyclovir in severe herpes virus infections. ): 229–235 (Jul 1982).Miller, W.H. ; Krasny, H.C. and Keeney, R.E. and Lietman, P.S. Antimicrobial Agents and Chemotherapy 19: 608–612 (1981).Spector, S.A.; Hintz, M.; Wybomy, C.; Connor, J.D. ; Rideout, J.L. ; Davis, L.G. American Journal of Medicine 73 (Suppl.
; Coster, D.J. Protect from light.We comply with the HONcode standard for trustworthy health information -
The most important adverse effect is crystalluria and elevated serum creatinine related to bolus intravenous administration. : Metabolic disposition of 9-(2-hydroxyethoxymethyl)guanine, a new antiviral drug. American Journal of Medicine 73 (Suppl. : Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. American Journal of Medicine 73 (Suppl. Journal of Antimicrobial Chemotherapy 5: 431–436 (1979).Corey, L.; Benedetti, J.K.; Critchlow, C.W. : Double-blind controlled trial of topical acyclovir in genital herpes simplex virus infections. ; Spector, S.A.; Blum, M.R. : Induction of both thymidine and deoxycytidine kinase activity by herpes virus. A prospective epidemiologic registry of acyclovir use during pregnancy was established in 1984 and completed in April 1999.
: Virus inhibition assay for measurement of acyclovir levels in human plasma and urine. Correspondence to : Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase. : Pharmacokinetics of orally administered acyclovir in patients with herpes progenitalis.
: Rapid acyclovir radioimmunoassay, using charcoal adsorption. ; Hintz, M.; Quinn, R.P.
; de Miranda, P.; King, D.H.; Page, D.A. To report SUSPECTED ADVERSE REACTIONS, contact Avet Pharmaceuticals Inc. at 1-866-901-DRUG (3784) or FDA at 1-800-FDA-1088 or[see USP Controlled Room Temperature]. : Acyclovir concentrations and tolerance during repetitive administration for 18 days. : Mechanism of action and selectivity of acyclovir. Antimicrobial Agents and Chemotherapy 21: 393–398 (1982b).Laskin, O.L. There were 749 pregnancies followed in women exposed to systemic acyclovir during the first trimester of pregnancy resulting in 756 outcomes.
and Morrison, J.M. ; Furman, P.A. Clinical Pharmacokinetics and Therapeutics 26: 718–728 (1979).Dubb, J.W. and Rogers, H.: Human pharmacokinetics of acyclovir (an antiviral agent) following rapid intravenous injection. Acyclovir is an antiviral agent only after it is phosphorylated in infected cells by a viral-induced thymidine kinase. Acyclovir incorporation into the growing viral deoxyribonucleic acid chain causes its termination. American Journal of Medicine 73 (Suppl. ; de Miranda, P.; Gerald, L. and Good, S.S.: A sensitive radioimmunoassay for the antiviral agent BW248U 9-(2-hydroxyethoxymethyl)guanine.
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