The efficacy of 30 micro gram intrathecal clonidine to alleviate labor pain reported in this study is somewhat surprising. Effects of added epinephrine. (Gautier, De Kock, Fanard, Hody) Staff Anesthesiologist, Clinique Ste. A Fifty patients were randomized, and 45 patients completed the study.

Pain, sensory levels, motor block, side effects, maternal vital signs, and fetal heart rate were systematically assessed.Patients administered BFCN had significantly longer analgesia (165+/-32 min) than those who received BF (90+/-21 min; P<0.001) or BFC (123+/-21 min; P<0.001).

The duration of CSE analgesia was measured from the time of IT drug administration until additional pain medication was requested. Anesth Analg 1998; 87:1309–15 A NESTHESIOLOGY 1997; 87 (3A):A898Naguib M, Yaksh TL: Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with μ and αAbram SE, Winne RP: Intrathecal acetyl cholinesterase inhibitors produce analgesia that is synergistic with morphine and clonidine in rats. J Pharmacol Exp Ther 1997; 282:86–92Bouaziz H, Herwitt C, Eisenach JC: Subarachnoid neostigmine potentiation of alpha2-adrenergic agonist analgesia. Oxytocin is in a class of medications called oxytocic hormones. For completeness, a nonparametric alternative for one-way ANOVA, the Kruskall-Wallis test, was applied along with a nonparametric multiple comparison procedure, the Wilcoxon rank sum test.

Anesthesiology 1994; 81:A1137. A P value

Results are expressed as means. Anesth Analg 1997; 84:1256-61.Chiari A, Lorber C, Taslimi R, Kohlberger P, Klimsha W: Combination of low dose intrathecal sufentanil and clonidine for obstetric analgesia [Abstract].

Uncomplicated course of pregnancy and normal fetal heart rate at the admission monitoring were mandatory inclusion criteria. 313 [266,379], and 1200 [1187,1448] ng/ml respectively. Anesthesiology 1994; 81:591-601.De Kock M, Wiederkher P, Laghmiche A, Scholtes JL: Epidural clonidine used as the sole analgesic agent during and after abdominal surgery: A dose-response study.

The duration of labor after intrathecal injections and the method of delivery were similar among the different groups (Intrathecal clonidine used as the sole analgesic agent at the dose of 15 micro gram provided adequate analgesia (100 and 84 min, respectively) in only 2 of the 10 patients considered.

Although hypotension may be a concern with the administration of intrathecal clonidine, our results, obtained in a limited number of patients, did not reveal any adverse maternal or fetal effects.The authors thank G. Byttebier, M.Sc., for helpful suggestions regarding statistical analysis, C. Jones, M.B.B.S., for critical review of the manuscript, and M. Deboschere for technical assistance.

It is also important information to carry with you in case of emergencies.URL of this page: https://medlineplus.gov/druginfo/meds/a682685.htmlTo use the sharing features on this page, please enable JavaScript.

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