WHO has provided a comprehensive definition […] For people with potency problems. Ethionamide tablets may be administered without regard to the timing of meals.The pharmacokinetic parameters of ethionamide following single oral-dose administration of 250 mg of Trecator film-coated tablets under fasted conditions to 40 healthy adult volunteers are provided in Table 1.Trecator tablets have been reformulated from a sugar-coated tablet to a film-coated tablet. However, pediatric dosages of 10 to 20 mg/kg p.o. Isoniazid: Ethionamide may increase the serum concentration of Isoniazid. Neurotoxic effects may be prevented or relieved by the coadministration of pyridoxine (see Pyridoxine monograph for dosing). It is essential, therefore, to give a suitable companion drug or drugs, the choice being based on the results of susceptibility testing. If serum transaminases become elevated during therapy, ethionamide and the companion antituberculosis drug or drugs may be discontinued temporarily until the laboratory abnormalities have resolved. There are no adequate and well-controlled studies in pregnant women. Dialysis. There are no adequate and well-controlled studies in pregnant women. Discontinue treatment immediately and institute appropriate therapy if signs or symptoms of SCAR develop.• Diabetes: Use with caution in patients with diabetes mellitus; may cause hypoglycemia.• Hepatotoxicity: May cause hepatotoxicity; monitor liver function tests at baseline and monthly.• Porphyria: Use not recommended; porphyria-inducing in animal and in vitro studies (WHO 2008).• Thyroid dysfunction: Use with caution in patients with thyroid dysfunction; hypothyroidism (reversible; with and without goiter) has been reported.• Appropriate use: Drug-resistant tuberculosis develops rapidly if ethionamide is used alone; must administer with other antituberculosis agents. Trecator tablets contain 250 mg of ethionamide. The management of patients with diabetes mellitus may become more difficult in those receiving ethionamide.No specific information is available on the treatment of overdosage with Trecator. The drug is approximately 30% bound to proteins. CONTRAINDICATIONS. Diabetic patients should be particularly alert for episodes of hypoglycemia.Periodic monitoring of thyroid function tests is recommended as hypothyroidism, with or without goiter, has been reported with ethionamide therapy.Trecator has been found to temporarily raise serum concentrations of isoniazid.
Ethionamide is essentially completely absorbed following oral administration and is not subjected to any appreciable first pass metabolism. Faster titration may be permissible if plasma level monitoring is available. Consultation with an expert in the treatment of drug-resistant tuberculosis is advised for patients in whom drug-resistant tuberculosis is suspected or likely. - Phenytoin. Ethionamide tablets may be administered without regard to the timing of meals.The pharmacokinetic parameters of ethionamide following single oral-dose administration of 250 mg of Trecator film-coated tablets under fasted conditions to 40 healthy adult volunteers are provided in Table 1.Trecator tablets have been reformulated from a sugar-coated tablet to a film-coated tablet. Adverse gastrointestinal effects appear to be dose related, with approximately 50% of patients unable to tolerate 1 gm as a single dose. Trecator may potentiate the adverse effects of other antituberculous drugs administered concomitantly. Select one or more newsletters to continue. The following conditions are contraindicated with this drug.
In general, continue therapy until bacteriological conversion has become permanent and maximal clinical improvement has occurred.Trecator (ethionamide tablets, USP) are supplied in bottles of 100 tablets as follows:250 mg, orange film-coated tablet marked "W" on one side and "4117" on reverse side, NDC 0008-4117-01.This product's label may have been updated. Data not available. Administer with or without meals.
Available for Android and iOS devices.Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. Metabolism is presumed to occur in the liver and thus far 6 metabolites have been isolated: 2-ethylisonicotinamide, carbonyl-dihydropyridine, thiocarbonyl-dihydropyridine, S-oxocarbamoyl dihydropyridine, 2-ethylthioiso-nicotinamide, and ethionamide sulphoxide. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels.
Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Description and Brand Names. Use during pregnancy is not recommended (Blumberg 2003).• Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin or eyes• Low thyroid level like constipation; trouble handling heat or cold; memory problems; mood changes; or burning, numbness, or tingling feeling• Low blood sugar like dizziness, headache, fatigue, feeling weak, shaking, fast heartbeat, confusion, increased hunger, or sweating• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
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