Routine administration of vitamin K to newborns. Vitamin K Administration Neonatal Clinical Guideline V2.0 Page 2 of 14 Summary Antenatal identification of high risk mothers – need for antenatal Vit K supplementation Healthy infants ≥ 34 weeks should receive 1mg im Infants < 34 weeks should receive 0.5mg im (IV in special circumstances) Antenatal discussion about post

Shearer MJ. Intravenous, Intramuscular .

Title: Table 1: GUIDELINES FOR THE ADMINISTRATION OF VITAMIN K TO REVERSE THE EFFECTS OF COUMADIN Author: tsimard Created Date: 4/7/2008 8:12:01 AM CDC twenty four seven. Unable to load your collection due to an error Vitamin K supplementation in cystic fibrosis. INR 4.5-10, no bleeding: 2012 ACCP guidelines suggest against routine use; 2008 ACCP guidelines suggest considering vitamin K1 (phytonadione) 1-2.5 mg PO once INR >10, no bleeding: 2012 ACCP guidelines recommend vitamin K1 PO (dose not specified); 2008 ACCP guidelines suggest 2.5-5 mg PO once; INR reduction observed within 24-48 hr, monitor INR and give additional vitamin K if needed Vitamin K deficiency bleeding (VKDB) in early infancy. Lee GR, Bithell TC, Forester J. Vitamin K prophylaxis in the newborn: indications and controversies. Human sources and absorption of vitamin K in relation to anticoagulation stability.

Prophylactic Dosing of Vitamin K to Prevent Bleeding.

Newborns are at risk for vitamin K deficiency bleeding (VKDB) caused by inadequate prenatal storage and deficiency of vitamin K in breast milk.

doi: 10.1212/WNL.0000000000005944.

VK, an essential, lipid-soluble vitamin that plays a vital role in the production of coagulation proteins, is found in green, leafy vegetables and in oils, such as … For permission to reprint or reproduce multiple copies, please see our Newborns are at risk for vitamin K deficiency bleeding (VKDB) caused by inadequate prenatal storage and deficiency of vitamin K in breast milk.

Replacement of clotting factors may be necessary in the presence of active bleeding . VKDB can lead to brain damage and death.The American Academy of Pediatrics recommends that A vitamin K shot can be administered after the first feeding at the breast, but not later than 6 hours of age. Burke CW. This site needs JavaScript to work properly. 2011 Jan;9(1):4-9. doi: 10.2450/2010.0034-10. Diseases & Conditions Factors associated with childhood cancer in a national cohort study.

An oral dose of vitamin K is not recommended. Springer Kristin M McCabe, Michael A. Adams, Rachel M. Holden. World Health Organization (WHO)

The risk of childhood cancer after neonatal exposure to vitamin K. Centers for Disease Control and Prevention (CDC). 209742-overview Acquired coagulation disorders.


Vitamin K should be administered to all neonates at birth or immediately afterwards.

Reports from the Canadian Paediatric Surveillance Program (CPSP) between 1997 and 2000 confirmed five cases of late VKDB, including one infant who received no vitamin K and two who received PO vitamin K, yielding an estimated incidence of 1 per 140,000 to 170,000 births Without adequate vitamin K intake, an induced protein (PIVKA-II) becomes measurable in blood. Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.

Diseases & Conditions



Molecular basis of vitamin K-dependent gamma-carboxylation. 2002 However, the protocols for administration (route of administration, dosage, number of doses) remain a subject of discussion. Please enable it to take advantage of the complete set of features! Current perspectives and practices of newborn vitamin K administration in low and middle income countries Patricia S Coffey, Emily Gerth-Guyette PATH, Seattle, WA, USABackground: Vitamin K prophylaxis can prevent vitamin K deficiency bleeding (VKDB), and current global recommendations support universal prophylactic use in newborns.



doi: 10.1038/jp.2016.30.Blood Rev. Hoffman R, Benz EJ, Shattil SJ, et al, eds.

Babies are born with very small amounts of vitamin K stored in their bodies, which can lead to serious bleeding problems like vitamin K deficiency bleeding (VKDB).

Infants who receive the vitamin K shot do not require further supplementation.To receive email updates about this topic, enter your email address.

Johnson PJ. Although an increased risk of solid tumour, associated vitamin K administration, can be definitively excluded, a low potential risk of lymphoblastic leukaemia in childhood can not be ruled out.
Vitamin K, an update for the paediatrician. 2018 Feb 5;2(2):CD008342. Neonatal Netw.



Infants who receive the vitamin K shot do not require further supplementation. VK, an essential, lipid-soluble vitamin that plays a vital role in the production of coagulation proteins, is found in green, leafy vegetables and in oils, such as …

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