dose may be increased in increments of 80 mg per day every 3 days provided the Continually monitor patients until steady state blood levels are achieved. Includes dosages for Breast Cancer, Non-Small Cell Lung Cancer, Breast Cancer - Adjuvant and more; plus renal, liver and dialysis adjustments.
Therefore, before using this product, tell your doctor or pharmacist of all the products you use. informational and educational purposes only. Your list will be saved and can be edited at any time.The above information is provided for general Paclitaxel 135 mg/m2 intravenously over 24 hours on day 1 followed by cisplatin 100 mg/m2 intraperitoneally on day 2 and paclitaxel 60 mg/m2 intraperitoneally on day 8. Two of the Phase 2 studies (92 patients) utilized an initial dose of 135 to 170 mg/m. /viewarticle/933706 Do not take Taxol if you are allergic to paclitaxel or any ingredients contained in this drug.Keep out of reach of children. Premedicate to prevent hypersensitivity reactions (eg, dexamethasone, diphenhydramine, H2 blockers)Previously untreated: 175 mg/m² IV over 3 hours q3Weeks (follow with cisplatin), OR 135 mg/m² IV over 24 hours q3Weeks (follow with cisplatin)Previously treated: Various regimens exist: 135-175 mg/m² IV over 3 hours q3WeeksNode positive (adjuvant chemotherapy): 175 mg/m² IV over 3 hours q3Weeks 4 times (with doxorubicin-containing regimen) Metastatic Disease (failure of initial chemotherapy or relapse within 6 months following adjuvant chemotherapy): 175 mg/m² IV over 3 hours q3Weeks135 mg/m² IV over 24 hours q3Weeks (follow with cisplatin) If baseline PMN <1500/m³, do not re-treat until PMN >1500/m³ and platelet count >100,000/m³If severe neutropenia occurs (PMN <500/m³ for 7 days), reduce subsequent doses by 20%Off-label: head/neck cancer, small-cell lung cancer, upper GI adenocarcinoma, hormone-refractory prostate cancer, NHL, urothelium transitional cell carcinoma, stage IIB-IV melanomaStevens-Johnson syndrome, toxic epidermal necrolysis, and extravasationThe drug should be administered under the supervision of an experienced cancer chemotherapy physician in a facility equipped to diagnose and manage complicationsThe drug is contraindicated in patients with solid tumor who have baseline neutrophil counts <1500 cells/m³ and in patients with AIDS-related Kaposi sarcoma who have baseline neutrophil counts <1000 cells/m³; perform frequent peripheral blood counts to monitor for occurrence of bone marrow suppression, primarily neutropenia, which may result in infectionFatal anaphylaxis and severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in patients despite premedicationPretreat all patients with corticosteroids, diphenhydramine, and H2 antagonistsDo not rechallenge patients who experience severe hypersensitivity reactions to the drugPatients with solid tumors or patients with AIDS-related Kaposi’s sarcoma with baseline neutrophil counts of <1,500 cells/mmAll patients should be pretreated with corticosteroids, diphenhydramine, and H2 antagonists; fatal reactions have occurred in patients despite premedication; patients who experience severe hypersensitivity reactions to paclitaxel should not be rechallenged with the drugBone marrow suppression (primarily neutropenia) is dose-dependent and is dose-limiting toxicity; should not be administered to patients with baseline neutrophil counts <1,500 cells/mmSevere conduction abnormalities have been documented in <1% of patients during paclitaxel therapy and in some cases requiring pacemaker placement; if patients develop significant conduction abnormalities during paclitaxel infusion, appropriate therapy should be administered and continuous cardiac monitoring should be performed during subsequent therapy with paclitaxelContact of the undiluted concentrate with plasticized polyvinyl chloride (PVC) equipment or devices used to prepare solutions for infusion is not recommended; in order to minimize patient exposure to the plasticizer DEHP [di-(2-ethylhexyl)phthalate], which may be leached from PVC infusion bags or sets, diluted paclitaxel solutions should preferably be stored in bottles (glass, polypropylene) or plastic bags (polypropylene, polyolefin) and administered through polyethylene-lined administration setsPaclitaxel should be administered through an in-line filter with a microporous membrane not greater than 0.22 microns; use of filter devices such as IVEX-2R filters which incorporate short inlet and outlet PVC-coated tubing has not resulted in significant leaching of DEHPMay increase the risk of cardiac dysfunction if received in conjunction with trastuzumab or anthracyclinesLactation: not known if excreted in breast milk, do not nurseA: Generally acceptable.
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