Only in cases of extreme overdosage or individual sensitivity do vital signs, including respiration, pulse, blood pressure, temperature, and EKG, need to be monitored. A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with promethazine HCl alone or in combination with The diagnostic evaluation of patients with this syndrome is complicated.
The impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore such agents should either be eliminated or given in reduced dosage in the presence of promethazine HCl (see Promethazine HCl Oral Solution may lead to potentially fatal respiratory depression.Use of Promethazine HCl Oral Solution in patients with compromised respiratory function (e.g. Phenergan Suppositories are for rectal … oz. Read all information given to you. It is freely soluble in water and soluble in alcohol.Promethazine HCl Syrup (promethazine hydrochloride syrup plain) Plain is useful for:Mild, uncomplicated allergic skin manifestations of Therapy adjunctive to meperidine or other analgesics for control of post-operative Sedation in both children and adults, as well as relief of apprehension and production of light It is important that Promethazine HCl Syrup (promethazine hydrochloride syrup plain) Plain is measured with an accurate
On succeeding days of travel, it is recommended that 25 mg be taken on arising and again before the evening meal. Take with or without food. Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities.The concomitant use of alcohol or other central-nervous-system depressants, such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers may enhance impairment (see Patients should be advised to report any involuntary muscle movements.A patient information leaflet is included and summarizes important information about promethazine.CNS Depressants – Promethazine HCl Oral Solution may increase, prolong, or intensify the sedative action of other central-nervous-system depressants such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. Alcohol 7%. Oxygen may also be administered.Limited experience with dialysis indicates that it is not helpful.It is important that Promethazine HCl Oral Solution is measured with an accurate measuring device (see The average oral dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary.
These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed.
[See USP Controlled Room Temperature. following structural formula:Promethazine HCl occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. Administration of 12.5 to 25 mg Promethazine HCl Syrup (promethazine hydrochloride syrup plain) Plain by the oral route at bedtime will provide sedation in children. Promethazine was nonmutagenic in the Salmonella test system of Ames.Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg of promethazine HCl. such as sedatives/hypnotics (including barbiturates), narcotics, You are encouraged to report negative side effects of prescription drugs to the FDA.
10, edetate disodium, ethyl alcohol, FD&C Blue No. Promethazine HCl Syrup (promethazine hydrochloride syrup plain) Plain is contraindicated for children under 2 years of age. ]Dispense in a tight, light-resistant container (USP/NF) with a child-resistant closure.Promethazine is an antihistamine which can be taken by mouth as an oral solution or tablet, rectally as a suppository, or by injection.
12.5 to 25 mg doses may be repeated, as necessary, at 4 to 6 hour intervals.For nausea and vomiting in children, the usual dose is 0.5 mg per pound of body weight, and the dose should be adjusted to the age and weight of the patient and the severity of the condition being treated.For prophylaxis of nausea and vomiting, as during surgery and the postoperative period, the average dose is 25 mg repeated at 4 to 6 hour intervals, as necessary.This product relieves apprehension and induces a quiet sleep from which the patient can be easily aroused. 2 years of age and older (see Clinical studies of promethazine formulations did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Alcohol 7%.
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