Gemfibrozil inhibits CYP2C8 and causes a … Free PMC article Insulin, PCNT, and F-actin expression in MIN-6 cells decreased after 15 minutes of stimulation with repaglinide, while no difference was observed at 2, 6, and 12 hours. (A) The… Intravenous glucose tolerance tests (IVGTTs) 0 to 10 minutes curves and area under… Trichrome immunofluorescence staining of mouse insulinoma (MIN-6) cells after repaglinide interference. Repaglinide is rapidly absorbed and has a rapid onset and short duration of action. PCNT (red), insulin (green), F-actin (light blue), DAPI (dark blue). Furthermore, there was no significant difference found in fasting insulin and postprandial insulin at baseline and at 15 weeks, while homeostasis model assessment β significantly increased. It has been shown to lower hemoglobin A1c (HbA1c) levels by 1.6% to 1.9%. The PCNT-F-actin pathway plays an important role in the repaglinide regulation process of on-demand insulin secretion. Certain medications may significantly decrease the hepatic metabolism of repaglinide, which may lead to serious adverse events. (A) The… Please enable it to take advantage of the complete set of features! 2019 Aug 15;10(8):421-445. doi: 10.4239/wjd.v10.i8.421. The first-phase glucose and insulin secretion of the intravenous glucose tolerance test improved in both groups, especially in the repaglinide group. (C) Glycemic variability parameters improved markedly from baseline to 15 weeks in both groups. 2014 Jun;170(6):901-8. doi: 10.1530/EJE-14-0052. When taken just prior to meals, it promotes the release of insulin that normally occurs with meals and is responsible for preventing blood glucose levels from becoming high.
Blood glucose levels, glycemic variability, β-cell function, and first-phase insulin secretion were compared between these 2 groups at baseline and at 15 weeks. Clipboard, Search History, and several other advanced features are temporarily unavailable. (A) The distribution of HbA1c changed obviously from baseline to 15 weeks for both groups. 2019 Nov 7;10:1318. doi: 10.3389/fphar.2019.01318. (B) fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) levels decreased significant from baseline to 15 weeks for both groups. Unable to load your delegates due to an error This site needs JavaScript to work properly. 1998;15 Suppl 4:S28-36. Characteristics of repaglinide and its mechanism of action on insulin secretion in patients with newly diagnosed type-2 diabetes mellitus. It achieves this by closing ATP -dependent potassium channels in the membrane of the beta cells . (C) The insulin level in the cell culture increased with time.
This agent is metabolized in the liver by CYP2C8 and CYP3A4 and its metabolites are excreted in the bile. The expression of pericentrin (PCNT), F-actin, and insulin were tested with immunofluorescence and enzyme-linked immunosorbent assay.All glycemic parameters and variability indexes significantly decreased from baseline to 15 weeks, while no significant difference was found between these 2 groups at baseline or at 15 weeks. Wolters Kluwer (B) The F-CP and 2-hour CP at baseline and 15 weeks. Following administration, repaglinide is absorbed rapidly and has a fast onset of dose-dependent blood-glucose lowering effect. Significant differences could be found at all timepoints between the repaglinide group and the HG group and the repaglinide group and the LG group ( 2019 Aug 15;10(8):421-445. doi: 10.4239/wjd.v10.i8.421.
The PCNT-F-actin pathway plays an important role in the repaglinide regulation process of on-demand insulin secretion.
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