http://circ.ahajournals.org/content/129/25_suppl_2/S1.fullThe elephant in the room, not being discussed, is that her biggest risk factor is by far, her age, and that NNT is quite large, if measurable.
The patients were treated at 138 US practices in the Patient and Provider Assessment of Lipid Management (PALM) registry in 2015. The 2016 guidelines identify that a mortality outcome has not been shown when used for secondary prevention. There are a number of decision points, including whether or not the intent is primary or secondary prevention, and tolerance to any medication that may beYou have not defined ‘healthy’- fitness, weight, appetite, fall risk, cognitive issues, polypharmacy, etc? During the COVID-19 pandemic, you need to continue to take your usual medicines and stay as healthy as possible.
Caution is recommended when statins are used in frail elderly patients, who may be more susceptible to drug-related myopathy and other side effects, 16 but Jacobson 17 has reviewed safety issues of statins in older patients and argues that the potential benefits …
It is acknowledged that the guidelines are not absolute, but rather are intended “…to launch one-on-one discussion between practitioner and patient.”Treatment decisions are based on risk regardless of age.
In contrast, statins would be indicated in elderly individuals with optimal risk factors since they exceed the ACC/AHA 7.5% risk threshold by age 65 (men) or 71 (women) and the NICE-UK 10% QRISK2 risk threshold by age 65 (men) or 68 (women) years. We acknowledge the provision of funding from the Australian Government Department of Health to develop and maintain this website.We are always looking for ways to improve our websiteReport a problem with medicines, medical devices or vaccines: The combination of these multiple risks and the ALLHAT-LLT data showing that statin therapy in older adults may be associated with an increased mortality rate 2 should be considered before prescribing or continuing statins for patients in this age …
This is largely based on the results of the PROSPER trial (Pravastatin in elderly individuals at risk for vascular disease) which enrolled subjects between the ages of 65 and 82 and included both primary and secondary prevention cohorts. Although the new study provides support for the use of statins in older adults, it isn’t the final answer.“While many are using this article to claim that statins in people over 75 are completely beneficial, more studies are needed before a conclusion can be made,” Amato said.But for some people, after consulting with their doctor, taking statins may be the right choice for them. Differences between other adverse events were not statistically significant. Read our ©2020 NPS MedicineWise. Mildred is a generally healthy 85-year-old female.
Increasing age is a risk factor for adverse events with statins. statins was associated with a decline in cognition function.10 Statin dose Meta-analyses suggest that 80% of the lipid-lowering effect of statins occurs at half the maximal statin dose.11 In older patients, the efficacy of statins for secondary prevention of acute myocardial infarction and death appears to be a class effect, with no difference observed between high or low potency statins… Older patients may have more comorbidities and be taking more concomitant drugs than the study populations in statin trials.
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