Fisher B, Costantino JP, Redmond CK, et al: Endometrial cancer intamoxifen-treated breast cancer patients: Findings from the NSABP B-14.J Natl Cancer Inst 86:527-537, 1994.
Since Killackey's first reportin 1985,[7] a number of reports have appeared in the literature associatingtamoxifen with endometrial cancer. He said the findings were impressive, and low-dose tamoxifen is a "very worthy idea to be explored. Bethesda, Maryland, National Cancer Institute, 1993.12. ObstetGynecol 84:987-995, 1994.
1. Generic drugs usually cost … [2] Interestingly, this effect was noted on both trabecular andcortical bone, with the effect on trabecular bone being more prominent.The clinical implications of such an effect include a significant decelerationin the osteoporotic process and a reduction in the incidence of hip fractures.Moreover, based on the findings that show a correlation between the durationof estrogenic treatment in postmenopausal women and the reduction of hipfractures,[3] the implication for tamoxifen is that perhaps a similar effectwould be achieved with long-term therapy.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG): Systemictreatment of early breast cancer by hormonal,cytotoxic,or immune therapy.Lancet 339:1-15, 71-85, 1992.
Compared with chemotherapeutic regimens commonly used for thetreatment of advanced breast cancer, tamoxifen appears to be much saferand to be considerably better tolerated by the patient. One point of interest is the aggressiveness of the reported endometrialtumors with regard to grade and stage.
And the study really needs to compare the 5 mg dose to the standard 20 mg dose to see if it's just as effective. Assikis VJ, Neven P, Jordan VC, et al: A realistic clinical perspectiveof tamoxifen and endometrial carcinogenesis. Killackey MA, Hakes TB, Pierce VK: Endometrial adenocarcinoma inbreast cancer patients receiving antiestrogens.
[9,10]To address this issue, we analyzed the grade and stage of the endometrialcarcinoma cases reported in the literature. About 35 percent of women in the tamoxifen group (and 39 percent in the placebo group) stopped treatment before the study was done. In contrast to what some investigators have argued, we donot see a massive increase in the frequency of endometrial cancer reportedwith tamoxifen duration longer than two years. Lobo RA, Pickar JH, Wild RA, et al: Metabolic impact of adding medroxyprogesteroneacetate to conjugated estrogen therapy in postmenopausal women. Tamoxifen is the oldest of the hormonal therapies, drugs that block the effects of estrogen in the breast tissue. However, women need to know that the current prevention strategies are very effective, he said. Findings presented at meetings are typically viewed as preliminary until published in a peer-reviewed journal.
"Before you stop taking a medication, let your doctor know about your side effects. Tamoxifen is the most widely prescribed endocrine therapy for breast cancer, with more than 7.5 million woman-years of clinical experience.
National Cancer Institute: SEER Cancer Statistics Review 1973-1990,Document #93-2789. [1] The role of estrogensin hindering this process has been clearly demonstrated. The Stockholm Breast Cancer Study Group. He said he'd like to see 15 years of follow-up. Eur J Cancer Part A 32A:1464-1476,1996. Although HDL isa more sensitive indicator of risk for atherosclerosis than is LDL, thereis evidence that both LDL and total cholesterol values can have profoundeffects on the incidence of cardiac disease.
Taking low-dose tamoxifen lowered the risk of recurrent or new breast cancer by 52 percent, the researchers reported. In addition, the risk of serious side effects, such as blood clots and endometrial cancer, were similar to that of the placebo, and less than what typically occurs with the 20 mg dose, De Censi said. 8. [2] No clear correlation of tamoxifen treatment with changes inHDL cholesterol levels is evident from available data. The daily dose of tamoxifen does not seem to play a key role; endometrialcancers were found in association with varied dosing schedules for tamoxifen.The duration of tamoxifen therapy also does not seem to be important inthis respect. "But, Marks added, the study doesn't have data for a long enough time period. Tamoxifen is a hormone therapy for breast cancer in both women and men.
Learn more about tamoxifen …
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