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Thioguanine is not used in maintenance because prolonged use carries a risk of splenomegaly and portal hypertension due to obstruction of liver sinusoids without cirrhosis. The patient journey centered model for a hospital institution Drug Administration Appointment Patient comes to Fee Per Service Patient Patient Patient Needs arrangement the Hospital Payment Examination diagnosis Follow-up? Although intro- spection was highly respected in the first years of modern scientific psy- chology, notably with the W rzburg school, soon it has gone into disrepute (for historical reviews, see Crovitz 1970; Humphrey 1963; Mandler and Mandler 1964; Shanon 1984).

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