The effects on parturition in rats are consistent with the species specific estrogen-lowering property produced by high doses of fluconazole.
Caution should be used in prescribing Fluconazole to patients with hypersensitivity to other azoles. Careful monitoring of prothrombin time in patients receiving Fluconazole and coumarin-type anticoagulants is recommended. After reconstitution with 24 mL of distilled water or Purified Water (USP), each mL of reconstituted suspension contains 10 mg or 40 mg of fluconazole USP.The reconstituted suspension meets the requirements of the Test 2 Dissolution in the USP monograph for Fluconazole for Oral Suspension, USP.The pharmacokinetic properties of fluconazole are similar following administration by the intravenous or oral routes.
(See The effects of Fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers.
A dosage of 12 mg/kg once daily may be used, based on medical judgment of the patient's response to therapy. Fluconazole is also used for other conditions. However, it may take several days for your symptoms to go away completely. (See Physicians should be aware that interaction studies with medications other than those listed in the Fluconazole showed no evidence of carcinogenic potential in mice and rats treated orally for 24 months at doses of 2.5 mg/kg/day, 5 mg/kg/day, or 10 mg/kg/day (approximately 2 to 7 times the recommended human dose). The mean AUCs of ethinyl estradiol and norethindrone increased by 24% (95% C.I.
Chloramphenicol is available under the following different brand names: Chloramphenicol IV and Chloromyectin. There is no need to adjust single dose therapy for vaginal candidiasis because of impaired renal function.
In cases of Fluconazole associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex, or age of the patient has been observed. These elevations occurred in patients with severe underlying disease, predominantly AIDS or malignancies, most of whom were receiving multiple concomitant medications, including many known to be hepatotoxic. A dosage of 400 mg once daily may be used, based on medical judgment of the patient's response to therapy. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.Fluconazole is primarily cleared by renal excretion as unchanged drug. Fluconazole hepatotoxicity has usually, but not always, been reversible on discontinuation of therapy. On the first day of dosing, Fluconazole increased the midazolam AUC and CA second randomized, double-dummy, placebo-controlled, cross-over study in three phases was performed to determine the effect of route of administration of Fluconazole on the interaction between Fluconazole and midazolam.
(See There have been published reports that an interaction exists when Fluconazole is administered concomitantly with tacrolimus, leading to increased serum levels of tacrolimus. Thirteen percent of children experienced treatment-related adverse events.
The pharmacokinetics of chloramphenicol succinate have been described by a 2-compartment model. Caution must be exercised if the concomitant use of Fluconazole and amiodarone is necessary, notably with high dose Fluconazole (800 mg).Fluconazole increases the effect of amitriptyline and nortriptyline. Patients who are anticipated to have severe granulocytopenia (less than 500 neutrophils cells/mmThe following dose equivalency scheme should generally provide equivalent exposure in pediatric and adult patients:Experience with Fluconazole in neonates is limited to pharmacokinetic studies in premature newborns. It may harm them.This leaflet summarizes the most important information about fluconazole. Do not use fluconazole for a condition for which it was not prescribed. The features seen in these infants include: brachycephaly, abnormal facies, abnormal calvarial development, cleft palate, femoral bowing, thin ribs and long bones, arthrogryposis, and congenital heart disease. Furthermore, in a randomized crossover study with 12 healthy volunteers, it was shown that Fluconazole delayed the elimination of fentanyl significantly. Male rats treated with 5 mg/kg/day and 10 mg/kg/day had an increased incidence of hepatocellular adenomas.Fluconazole, with or without metabolic activation, was negative in tests for mutagenicity in four strains of Fluconazole did not affect the fertility of male or female rats treated orally with daily doses of 5 mg/kg, 10 mg/kg or 20 mg/kg or with parenteral doses of 5 mg/kg, 25 mg/kg or 75 mg/kg, although the onset of parturition was slightly delayed at 20 mg/kg PO. In patients with fungal meningitis, fluconazole concentrations in the cerebrospinal fluid (CSF) are approximately 80% of the corresponding plasma concentrations.A single oral 150 mg dose of fluconazole administered to 27 patients penetrated into vaginal tissue, resulting in tissue: plasma ratios ranging from 0.94 to 1.14 over the first 48 hours following dosing.A single oral 150 mg dose of fluconazole administered to 14 patients penetrated into vaginal fluid, resulting in fluid: plasma ratios ranging from 0.36 to 0.71 over the first 72 hours following dosing.In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug.
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