To clarify this enigma we analyzed sperm motility in semen and epididymal sperm samples. Effects of estradiol administered in normal and gonadotropin-releasing hormone-deficient men.Sex differences and androgen-dependent regulation of aromatase (CYP19) mRNA expression in the developing and adult rat brain.Sex differences and androgen-dependent regulation of aromatase (CYP19) mRNA expression in the developing and adult rat brain.17beta-Estradiol and environmental estrogens significantly affect mammalian sperm function.Many of the estrogen effects are mediated by the cognate receptors, ligand-activated transcription factors, binding to estrogen-responsive elements of the hormone-responsive genes (Steroid hormone receptors: many actors in search of a plot.Ontogeny of estrogen receptor β (ERβ) in the rat testis.Estrogen receptor knock-out mice: molecular and endocrine phenotypes.Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs.Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs.Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs.Although estrogens have well-known genomic action, they also exert rapid nongenomic effects, which are mediated by classical or still poorly characterized receptors (Genomic and nongenomic effects of estrogens: molecular mechanisms of action and clinical implications for male reproduction.Mitochondria from ejaculated human spermatozoa do not synthesize proteins.Targeted disruption of the oestrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.Regulation of rat testis gonocyte proliferation by platelet-derived growth factor and estradiol: identification of signaling mechanisms involved.Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. Radiata).Tamoxifen is a synthetic nonsteroidal type I estrogen antagonist that competitively blocks estrogen receptors and inhibits the action of agonists, but, because of its own agonistic property, it also induces some estrogenic responses (Receptor blockers—general aspects with respect to their use in domestic animal reproduction.Receptor blockers—general aspects with respect to their use in domestic animal reproduction.Receptor blockers—general aspects with respect to their use in domestic animal reproduction.Morphological effects of catecholestrogens on the cells of the seminiferous tubules of Sprague-Dawley rats.Synergistic activation of estrogen receptor with combinations of environmental chemicals.Apoptosis pattern elicited by estradiol treatment of the seminiferous epithelium of the adult male rat.Tamoxifen is usually used in the treatment of breast cancer (Treatment of gynaecomastia with tamoxifen, a double-blind crossover study.Clomiphene or tamoxifen for idiopathic oligo/asthenospermia.Effects of tamoxifen on the fertility of male rats.Treatment of idiopathic oligozoospermia with tamoxifen—a randomized controlled study.Tamoxifen treatment of idiopathic oligozoospermia: effect on hCG-induced testicular steroidogenesis and semen variables.Effect of tamoxifen on spermatogenesis and tubular morphology in rats.In other studies, it was also pointed out that long-term oral tamoxifen treatment caused reduction in viable litters sired by treated male rats after 60 days of exposure (Effect of paternal administration of an antiestrogen, tamoxifen on embryo development in rats.Randomly bred 75-day-old male and female rats of the Wistar strain were bred and maintained under specific pathogen-free conditions in the vivarium of the Center of Immunology and Clinical Biochemistry Research (CIBICI-CONICET) of the National University of Cordoba, Argentina.
The copulatory plug was absent or severely impaired in tamoxifen-treated males. A. Pasbjerg Last Modified Date: August 17, 2020 . Treatment of patients with "idiopathic" oligospermia for 6 to 9 months resulted in a significant increase in gonadotropin, testosterone, and estradiol levels.
In concordance with the results observed in semen samples, significantly altered values were observed in animals from group T versus group C, when epididymal sperm concentration and sperm motility were assayed (To confirm the origin of the sperm alterations observed in semen and epididymal samples, we performed histologic analysis of the testis from all animals under study.

Vaginal lavage was checked daily (9:00 Females were removed from male cages early the next morning, and the vaginal lavage fluid was examined immediately for the presence of sperm or copulatory plug, which was analyzed and also used as evidence of mating. eCollection 2018 Mar.Tang KF, Zhao YL, Ding SS, Wu QF, Wang XY, Shi JQ, Sun F, Xing JP.J Zhejiang Univ Sci B.

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