Am J Kidney Dis 2002;39(2 suppl 1):S46Chronic kidney disease is defined as the presence of kidney damage or a reduction in GFR for a period of three months or longerK/DOQI = Kidney Disease Outcomes Quality Initiative; GFR = glomerular filtration rateAdapted with permission from National Kidney Foundation. Weiner DE, Prag KA. Nguyen TV,
TORSEMIDE (tor'se-mide) Demadex Classifications: electrolyte and water balance agent; loop diuretic Prototype: Furosemide Pregnancy Category: B: Availability. Hirshfeld S. Eisenberg DM, Dr. Munar received her doctorate of pharmacy degree at the University of Southern California School of Pharmacy, Los Angeles.HARLEEN SINGH, PharmD, is a clinical assistant professor in the Department of Pharmacy Practice at Oregon State University College of Pharmacy.
Resources are available to assist in dosing decisions for patients with chronic kidney disease. 4th ed.
New York, N.Y.: McGraw-Hill, 2005:429–52.Neurontin (Gabapentin) [Package insert]. Metabolites of meperidine (Demerol), dextropropoxyphene (propoxyphene [Darvon]), morphine (Duramorph), tramadol (Ultram), and codeine can accumulate in patients with chronic kidney disease, causing central nervous system and respiratory adverse effects.Adverse renal effects of NSAIDs include acute renal failure; nephrotic syndrome with interstitial nephritis; and chronic renal failure with or without glomerulopathy, interstitial nephritis, and papillary necrosis.Short-term use of NSAIDs is generally safe in patients who are well hydrated; who have good renal function; and who do not have heart failure, diabetes, or hypertension.Drug dosing requirements for statins and for other commonly prescribed medications that require dosing adjustments in patients with chronic kidney disease are listed in 50% dose reduction in patients with a GFR less than 30 mL per minute per 1.73 m20 to 40 mg daily Maximal dosage: 80 mg daily (immediate release) or 60 mg daily (extended release)Use with caution in patients with a GFR less than 30 mL per minute per 1.73 mStarting dosage should not exceed 10 mg daily in patients with a GFR less than 30 mL per minute per 1.73 mRecommended starting dosage is 5 mg daily in patients with a GFR less than 30 mL per minute per 1.73 mRecommended starting dosage is 5 mg daily in persons with a GFR less than 10 mL per minute per 1.73 m50% dose reduction in patients with a GFR less than 30 mL per minute per 1.73 m20 to 40 mg daily Maximal dosage: 80 mg daily (immediate release) or 60 mg daily (extended release)Use with caution in patients with a GFR less than 30 mL per minute per 1.73 mStarting dosage should not exceed 10 mg daily in patients with a GFR less than 30 mL per minute per 1.73 mRecommended starting dosage is 5 mg daily in patients with a GFR less than 30 mL per minute per 1.73 mRecommended starting dosage is 5 mg daily in persons with a GFR less than 10 mL per minute per 1.73 m400 to 1,400 mg twice daily (GFR > 30 to 59) 200 to 700 mg daily (GFR > 15 to 29)400 to 1,400 mg twice daily (GFR > 30 to 59) 200 to 700 mg daily (GFR > 15 to 29)
et al. Meperidine associated mental status changes in a patient with chronic renal failure. Comprehensive alcohol & food interactions for torsemide. Type in a drug name to check for interactions with Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some mixtures of medications can lead to serious and even fatal consequences.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do nonsteroidal anti-inflammatory drugs affect blood pressure? Pitt B, Please check with a physician if you have health questions or concerns. Hyperlipidemima. Recommended methods for maintenance dosing adjustments are dose reductions, lengthening the dosing interval, or both. Zoppi A, Metformin (Glucophage) [Package insert]. for the Randomized Aldactone Evaluation Study Investigators. Infect Dis Clin North Am 2004;18:556–67, with additional information from referenceDosage adjustment (percentage of usual dosage) based on GFR (mL per minute per 1.73 mTo avoid nephrotoxicity it is recommended that the patient have a daily urine output of 1 mL for every 1.3 mg of acyclovir administeredAdapted with permission from Livornese LL Jr, Slavin D, Gilbert B, Robbins P, Santoro J. Kales SN, Oral route (Powder for Solution) Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening.Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Cushman WC,
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