Haemodialysis is unlikely to be of benefit.Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol. The 40mg dose should only be prescribed in patients with severe hypercholesterolaemia at high cardiovascular risk (see Section 4.2).In the Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study, the effect of rosuvastatin on the occurrence of major atherosclerotic cardiovascular disease events was assessed in 17,802 men (≥50 years) and women (≥60 years) Study participants were randomly assigned to placebo (n=8901) or rosuvastatin 20 mg once daily (n=8901) and were followed for a mean duration of 2 years.LDL-cholesterol concentration was reduced by 45% (p<0.001) in the rosuvastatin group compared to the placebo group.In a post-hoc analysis of a high-risk subgroup of subjects with a baseline Framingham risk score>20% (1558 subjects) there was a significant reduction in the combined end-point of cardiovascular death, stroke and myocardial infarction (p=0.028) on rosuvastatin treatment versus placebo.
It allows continued monitoring of the benefit/risk balance of the medicinal product. Reproductive toxicity was evident in rats, with reduced litter sizes, litter weight and pup survival observed at maternally toxic doses, where systemic exposures were several times above the therapeutic exposure level. LiverTox® provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury attributable to prescription and nonprescription medications and selected herbal and dietary supplements. The 40 mg dose is contraindicated with concomitant use of a fibrate.
The medications fenofibrate (TriCor, Fenoglide, … If it is suspected a patient has developed interstitial lung disease, statin therapy should be discontinued.Some evidence suggests that statins as a class raise blood glucose and in some patients, at high risk of future diabetes, may produce a level of hyperglycaemia where formal diabetes care is appropriate. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.Many drugs can interact with carbamazepine, and some drugs should not be used together.
There is evidence that red yeast rice can help lower your LDL cholesterol. Store in the original package in order to protect from light.Rosuvastatin tablets are available in Polyamide /Al/PVC/ Aluminium blisters and HDPE bottle with polypropylene closure.
Wear protective clothing and use Report any new or worsening symptoms to your doctor, such as: sudden mood or behavior changes, depression, loss of appetite, right-sided upper stomach pain, dark urine;This is not a complete list of side effects and others may occur. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. The choice of start dose should take into account the individual patient's cholesterol level and future cardiovascular risk as well as the potential risk for adverse reactions (see below). To interpret your test results, use these general guidelines.For most children, the National Heart, Lung, and Blood Institute recommends one cholesterol screening test between the ages of 9 and 11, and another cholesterol screening test between the ages of 17 and 21.If your child has a family history of early-onset heart disease or a personal history of obesity or diabetes, your doctor might recommend earlier or more-frequent cholesterol testing.Lifestyle changes such as exercising and eating a healthy diet are the first line of defense against high cholesterol. Rosuvastatin is contraindicated in pregnancy and lactation. LDL apheresis) or if such treatments are not appropriate.Prevention of major cardiovascular events in patients who are estimated to have a high risk for a first cardiovascular event (see Section 5.1), as an adjunct to correction of other risk factors. In exceptional circumstances, where prolonged systemic fusidic acid is needed, e.g.
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In situations where coadministration of these medicinal products with rosuvastatin is unavoidable, the benefit and the risk of concurrent treatment and rosuvastatin dosing adjustments should be carefully considered (see Section 4.5).
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