Br J Clin Pharmacol 15 (1983): 287-93 "Product Information. However, failing this in adults, an initial double (loading) dose of 1 g (= 600 mg base), or in children 10 mg base/kg may be taken in two divided doses, six hours apart. You can also search for this author in Chloroquine taken in the dose recommended for malaria prophylaxis can reduce the antibody response to primary immunization with intradermal human diploid-cell rabies vaccine.Praziquantel: In a single-dose interaction study, Chloroquine has been reported to reduce the bioavailability of praziquantel.Tamoxifen: Concomitant use of Chloroquine with drugs known to induce retinal toxicity such as tamoxifen is not recommended (see There is insufficient evidence regarding the carcinogenicity of Chloroquine in experimental animals.Chloroquine is reported in the literature to be a weak genotoxic agent which may elicit both gene mutations and chromosomal/DNA breaks. You can also search for this author in A. Alexandre & Cristiana T. NascimentoNational Institute of Infectious Disease, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, BrazilLaboratory of Pharmacokinetics (SEFAR), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, BrazilLaís Bastos da Fonseca, Diego Medeiros Dias da Silva & Douglas Pereira PintoInstitute René Rachou, Oswaldo Cruz Foundation (FIOCRUZ), Belo Horizonte, BrazilDanielle Fonseca Rodrigues, Ana Carolina Rios Silvino, Taís Nóbrega de Sousa & Cristiana Ferreira Alves de BritoYou can also search for this author in Therefore, close monitoring of serum cyclosporine level is recommended and, if necessary, Chloroquine should be discontinued.Mefloquine: Co-administration of Chloroquine and mefloquine may increase the risk of convulsions.The blood concentrations of Chloroquine and desethylChloroquine (the major metabolite of Chloroquine, which also has antimalarial properties) were negatively associated with log antibody titers. (ABSTRACT TRUNCATED AT 250 WORDS)Please check your email for instructions on resetting your password. Chloroquine phosphate, USP is an antimalarial and amebicidal drug.Chemically, it is 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino] quinoline phosphate (1:2) and has the following structural formula:Each tablet contains 250 mg of Chloroquine phosphate USP, equivalent to 150 mg Chloroquine base.Chloroquine undergoes appreciable degradation in the body. Concomitant use of cimetidine should be avoided.Insulin and other antidiabetic drugs: As Chloroquine may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or other antidiabetic drugs may be required.Arrhythmogenic drugs: There may be an increased risk of inducing ventricular arrhythmias if Chloroquine is used concomitantly with other arrhythmogenic drugs, such as amiodarone or moxifloxacin.Ampicillin: In a study of healthy volunteers, Chloroquine significantly reduced the bioavailability of ampicillin.
This work was supported in part by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, BrazilVice-presidency of Research and Biological Collections, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, BrazilLiverpool School of Tropical Medicine, Liverpool, UKAndré Daher, Ghait Aljayyoussi, Feiko O. ter Kuile & David G. LallooTropical Medicine Research Center of Rondonia (CEPEM), Porto Velho, Rondonia, BrazilFederal University of Rondonia (UNIR), Porto Velho, Rondonia, BrazilResearch Institute Leônidas & Maria Deane, FIOCRUZ, Manaus, BrazilFoundation of Tropical Medicine Dr. Heitor Vieira Dourado, Manaus, BrazilMarcus V. G. Lacerda, Márcia A. Each subject received two tablets of chloroquine sulfate (300 mg base) only. MAAA, CTN, collected the clinical data. This paper presents the current state of knowledge on chloroquine disposition, with special emphasis on stereoselectivity and microsomal metabolism. a CYP2D6 haplotype inferred using Phase software.
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