conceived the study. Three additional points need addressing. Taylor, D. In our study population of clozapine discontinuers, we found no cases of myocarditis. Of the atypical antipsychotics, risperidone, quetiapine and aripiprazole, despite having less observations than other atypicals, seem to perform relatively poorly on the outcome of psychiatric ward readmission in clozapine discontinuers ( During follow-up, 278 persons died (21.9% unnatural and 78.1% natural/undetermined causes). Taylor, David ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Treatment options for clozapine resistanceAssociation of antipsychotic polypharmacy vs monotherapy with psychiatric rehospitalization among adults with schizophreniaReal-world effectiveness of antipsychotic treatments in a nationwide cohort of 29 823 patients with schizophreniaLong-acting injectable versus oral antipsychotics in schizophrenia: a systematic review and meta-analysis of mirror-image studiesClozapine, but not olanzapine, disrupts conditioned avoidance response in rats by antagonizing 5-HT 2A/2C receptorsThe long-term effects of antipsychotic medication on clinical course in schizophrenia‘Breakthrough’ dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over timeTautiluokitus Osa 1: Systemaattinen Osa.
Rahimi, Tamanna and lower risks of psychiatric ward readmission, treatment failure and mortality) compared with no antipsychotic use and other antipsychotics. … the use of clozapine, or any combination of these factors. Yang, Shu-Yu and Those who discontinued clozapine had a longer history of illness and more hospitalizations before clozapine and tended to be older. and A.T. designed the study. A.Coker. Lancet 2009;Epub ahead of print-DOI:10.1016/SO140-6736(09)60742-X. Our findings point out the importance of enhancing psychiatrists' ability to handle manageable side effects to minimize discontinuations and maximize the benefits of clozapine in patients with treatment-resistant schizophrenia. Moreover, there is also evidence of reduced effectiveness of antipsychotics after reintroduction or sustained use, in particular for clozapine. Lamia, Dellagi Among those not using antipsychotics after clozapine cessation, we observed a ≥4-fold increased mortality rate compared with those using any antipsychotic. Damkier, P. Tsai, Shang-Ying and 2011. Davis, M. C. Within-individual results were analysed with stratified Cox proportional hazard regression models in which each individual formed his or her own stratum. Indeed, mortality is higher in schizophrenia than in the general population in people receiving any antipsychotic (1). 1 It exhibits its effect through antagonism at dopaminergic, serotonergic, adrenergic, cholinergic, muscarinic, and histaminergic receptors. Unable to load your collection due to an error Fitzgerald, Paul B. Chen, Chiao-Chicy
They, however, conclude that clozapine is associated with a significantly increased risk of death compared to that of the general population and that the common causes of clozapine This study was funded by the Finnish Ministry of Social Affairs and Health through the developmental fund for Niuvanniemi Hospital.
Correll, Christoph U. Median follow-up time was 5.4 (interquartile range, 1.4–10.5) years and 50% of the entire study population ( Olanzapine and antipsychotic polypharmacy associations remained significant in the planned sensitivity analysis that restricted inclusion to those who did not re-start clozapine (Supplementary Fig. Grégoire, Claire-Anne The aim of this retrospective chart-review study was to investigate the causes of clozapine discontinuation in patients with treatment-resistant schizophrenia. Liao, Ya-Tang Topliss, Duncan J. Karim, Tabbane
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