The electronic records were maintained and regularly updated with clinical data collected before ablation, ablation procedure data, and data from subsequent follow-up visits in addition to all unscheduled visits, telephone encounters, and communication with referring physicians.Arrhythmia recurrence was defined as electrocardiographic documentation of an atrial tachyarrhythmia, lasting ≥30 seconds, on a 12-lead electrocardiogram, event recording, or Holter monitor recording with or without symptoms. A 2-sided The primary variable of interest which was the time interval between the very first PersAF diagnosis and the ablation procedure was analyzed both as a continuous log-transformed variable and categorized into quartiles. It’s rare, but if you have persistent or chronic AFib, you might need a second ablation within 1 year.

It's a type of cardiac ablation, which works by scarring or destroying tissue in your heart to disrupt faulty electrical signals causing the arrhythmia.Atrial fibrillation ablation may be used if medications or other interventions to control an irregular heart rhythm don't work. By continuing to browse this site you are agreeing to our use of cookies.Various ablation strategies of persistent atrial fibrillation (PersAF) have had disappointing outcomes, despite concerted clinical and research efforts, which could reflect progressive atrial fibrillation–related atrial remodeling.Two-year outcomes were assessed in 1241 consecutive patients undergoing first-time ablation of PersAF (2005–2012). Other combinations of these arrhythmias were observed in the remaining 3%.The study population was categorized into quartiles of the time interval between the very first diagnosis of PersAF and the ablation procedure (≤1, 1.1–3.0, 3.1–6.5, >6.5 years). In all cases, PVI was performed in addition to ablation at the posterior wall and septal to the right pulmonary veins. These 177 patients were subsequently followed up for at least another 24 months, by means of electrocardiogram and 24 h Holter monitoring. More specifically, the proportion of patients who met the cardioversion within 7 days criterion could not be determined. With longer diagnosis-to-ablation times, there was evidence of a greater degree of atrial remodeling as reflected by atrial dilatation and higher levels of markers of inflammation and hemodynamic strain. These patients were excluded from the current analysis because of lack of information about the primary variable of interest that the study aimed to assess. Persistent AF was defined in concordance with the published guidelinesOur AF ablation protocol and periprocedural anticoagulation strategies were previously reported in detail.A phased-array intravascular ultrasound catheter (Siemens AG Inc, Malvern, PA) was placed in the right atrium to assist with performing trans-septal punctures, guide catheter location and manipulation within the left atrium (LA), and monitor for complications during the procedure. The assay reliably measures BNP concentrations ranging from 5 to 1300 pg/mL.Clinical and follow-up data were collected before the procedure on the day of ablation and subsequent follow-up visits in all patients and continuously updated using electronic medical records. The Johns Hopkins Minimally-Invasive Cardiac Surgical Program currently offers minimally-invasive surgical radiofrequency ablation for patients who suffer from atrial fibrillation..

With longer diagnosis-to-ablation time (based on quartiles), there was a significant increase in recurrence rates in addition to an increase in B-type natriuretic peptide levels (In patients with PersAF undergoing ablation, the time interval between the first diagnosis of PersAF and the catheter ablation procedure had a strong association with the ablation outcomes, such as shorter diagnosis-to-ablation times were associated with better outcomes and in direct association with markers of atrial remodeling.Various ablation strategies for persistent atrial fibrillation (PersAF) have had disappointing outcomes despite concerted clinical and research efforts.Chronicity of the arrhythmia is associated with progressive atrial remodeling.The study shows that the time interval between the very first diagnosis of PersAF and catheter ablation is strongly associated with the ablation outcomes; shorter diagnosis-to-ablation times were associated with better outcomes.Longer diagnosis to ablation time for PersAF was associated with markers of atrial remodeling.Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with increased morbidity and mortality.

Antiarrhythmic medications were generally continued during this 3-month period. For all patients with a history of typical atrial flutter (AFL), a cavotricuspid isthmus line was performed with confirmation of bidirectional block as an end point.All patients had trans-thoracic echocardiograms within 3 months before the ablation procedures to determine LA size and left ventricular function. Recurrent arrhythmias were AF, AFL, AF/AFL, and atrial tachychardia in 60.4%, 13.6%, 20.7%, and 2.3%, respectively. Similarly, although all patients in this study were designated as patients with PersAF in concordance with the published guidelines, this study was primarily based on clinical documentation in the medical records of PersAF diagnosis and information regarding whether this was based on a continuous AF episode >7 days versus >48 hours with a cardioversion could not be determined with precision.

In fact, various ablation strategies of PersAF have had disappointing outcomes, despite concerted clinical and research efforts, and recurren… The remaining 3.9% were performed for other combinations of these arrhythmias. This site needs JavaScript to work properly. The actuarial atrial arrhythmia recurrence rate was 13.0% at 2 years, 21.8% at 3 years, 35.0% at 4 years, 46.8% at 5 years, and 54.6% at 6 years. Radiofrequency ablation (RFA) is a minimally invasive procedure that is performed at a doctor’s office or a hospital.

Plasma CRP concentrations were assayed by using the BNII analyzer protocol (Dade Behring, Deerfield, IL). Radiofrequency ablation (or RFA) is a procedure used to reduce pain.

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