University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences. den Hollander, J.-M. Descamps, A. Devidas, P. Di Gregorio, G. Di Perri, D. Dockrell, P. Domingo, S. Echevarría, B. Elharrar, S. Esser, V. Estrada, A. Fakoya, G. Fätkenheuer, V. Faucherre, J. Fehr, G. Ferrea, C. Fontier Roussel, L. Force, G. Force, R. Fox, H. Furrer, M.J. Galindo Puerto, H. Gallais, J.-A.
All the authors evaluated the study results, reviewed and edited the manuscript, and vouch for the completeness and accuracy of the data presented.Patients were assessed for eligibility and were randomly assigned to undergo either prospective or retrospective HLA-B*5701 testing between April and September 2006 at 265 centers in 19 countries. Abacavir was initiated in eligible patients on day 1 of the study, followed by an observation period of 6 weeks (Randomization was based on a computer-generated, centralized schedule, with a block size of four and stratification according to self-reported race (white vs. nonwhite), history of receipt of antiretroviral therapy (none vs. any), and intention to commence a new nonnucleoside reverse-transcriptase inhibitor between the time of the visit to assess eligibility and day 1 of the study (the first day of abacavir therapy).Blood samples for use in HLA-B*5701 screening were collected from all patients during the evaluation period. Patients could not have previously received abacavir, but they could have received other antiretroviral drugs. Turnaround time is defined as the usual number of days from the date of pickup of a specimen for HLA58 : The human leukocyte antigen (HLA) genes help the immune system recognize and respond to foreign substances (such as viruses and bacteria). Results were similar for the subgroup of white patients (For immunologically confirmed hypersensitivity reaction, the HLA-B*5701 allele was associated with a positive predictive value of 47.9% and a negative predictive value of 100%.
Abacavir is a nucleoside reverse transcriptase inhibitor used for combination antiretroviral therapy for treating human immunodeficiency virus (HIV) infection. The genetic sequences coding for the HLA-B*5701are probed and reported as positive if the allele is … Eligible patients were adults with HIV-1 infection and a preestablished clinical need for treatment with an antiretroviral-drug regimen containing abacavir but with an unknown HLA-B*5701 status. Santamaria, V. Molotilov, M. Montroni, J. Moreau, E. Morgan, P. Morlat, G. Moshkovich, M. Moutschen, M. Müller, A. Mutz, L. Naumova, M. Nelson, A. Ocampo, O. Øktedalen, C. Oliveira, P. Ortolani, G. Pagano, M. Partisani, G. Pastore, A. Paula Reis, J. Pedreira Andrade, E. Pedrol, G. Pellizzer, M.J. Pérez Elías, P. Perfezou, P. Perre, S. Pheng Quah, P. Philibert, G. Pialoux, L. Piroth, A. Plettenberg, D. Podzamczer, A. Poggio, J. Portilla, S. Portsmouth, J. Portu Zapirain, L. Potemina, T. Prazuck, L.-J. Alleman, C. Alonso Villaverde, G. Angioni, A. Antinori, C. Aquilina, K. Arastéh, J.R. Arribas, J. Arumainayagam, H. Aumaitre, M. Beniowski, M. Bentata, J. Berenguer, C. Bergin, J.-F. Bergmann, B. Bernasconi, J.-M. Besnier, A. Biglino, W.L. Informed Consent for Genetic Testing ; Multiple Whole Blood EDTA Genotype Tests; Pharmacogenomic Associations …
Blok, A. Boron-Kaczmarska, M. Branco, N.H. Brockmeyer, W. Bronsveld, E. Brottier-Mancini, A. Bykov, U. Caixas, P. Caramello, A. Cargnel, M. Castaño, A.M. Cattelan, M. Cavassini, D. Chadwick, J.-P. Chave, J.-M. Chennebault, F. Chiodo, A. Chirianni, M. Chowers, S. Christensen, J. Chuah, B. Clotet, N. Clumeck, L.L. It is a HLA-B5701 (For abacavir Hypersensitivity) Test that screens for serious conditions. The manuscript was written by two academic authors and four industry authors. To test for the There are approximately 33 million people worldwide who are living with HIV/AIDS We acknowledge Sara Bedrosian, BA, BFA and William D. Dotson, PhD from the CDC for reviewing this document and providing comments.This project was funded in part by the CDC Cooperative Agreement #1U38GD000070, Pharmacogenomics Education Program (PharmGenEdâ¢): Bridging the Gap between Science and Practice. No case of clinically diagnosed hypersensitivity reaction in the prospective-screening group was immunologically confirmed.
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