0000037929 00000 n Blood tests may be needed to check for unwanted effects. 09, 2006. http://www.ginasthma.com213. )If symptoms are controlled and current dosage is tolerated, maintain infusion rate and recheck serum concentration at 24-hour intervals. Expert panel report: guidelines for the diagnosis and management of asthma-update on selected topics 2002. No.94-3042A. Theophylline is a very effective bronchodilator medicine. Do not use Deriphyllin Retard 300 Tablet if you are allergic to - Etofylline/Etophylline, Theophylline If you have heart disease, liver or kidney disease, drug or alcohol addiction, consult your doctor before using Deriphyllin Retard 300 Tablet. %�쏢 After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects.

(See Warning/Precautions under Cautions and see Interactions. NIH Publ. Theophylline 200, 400 and 800 mg in 5% dextrose injection prescribing information. A reliably absorbed slow-release formulation will decrease fluctuations and permit longer dosing intervals.See Warning/Precautions under Cautions and also see Interactions for information on risk factors for decreased theophylline clearance.Children and adolescents 6–15 years of age weighing <45 kgInitially, 12–14 mg/kg (maximum 300 mg) daily in divided doses; after 3 days, Children and adolescents 6–15 years of age weighing >45 kgInitially, 300 mg daily in divided doses; after 3 days, Children and adolescents 6–15 years of age with risk factors for reduced theophylline clearance or in whom serum concentrations cannot be monitoredInitially, 12–14 mg/kg (maximum 300 mg) daily in divided doses; after 3 days, Adjust dosage based on peak serum theophylline concentrations and clinical response and tolerance of patient as follows:The clinical characteristics of each patient must be considered when applying these general dosage recommendations to individual patients. No. All rights reserved. From GINA website. (See Warnings/Precautions under Cautions and also see Interactions. FDA(Food and Drug Administration) has determined Theophylline in pregnancy category C, which specifies that there was some fetal harm in animals and there is no data which shows … If therapy is resumed, decrease subsequent dosage by ≥50% and recheck serum concentration after 3 days to guide further dosage adjustmentWhen adjusting dosage in this manner, ensure that dosage in previous 48 hours was reasonably typical of prescribed regimen and that patient did not miss a dose or take an additional dose in this time period.For acute exacerbations of reversible airway obstruction (when an inhaled, short-acting βSome experts suggest initiating therapy with a theophylline dosage of 10 mg/kg (up to 300 mg) daily in divided doses, with titration up to a usual maximum dosage of 800 mg daily in divided doses.Following the loading dose, titrate theophylline dosage for subsequent therapy in adults using an immediate-release preparation as follows:Patients with more rapid metabolism, identified clinically by higher than average dosage requirements, may require smaller doses given more frequently to prevent breakthrough symptoms resulting from low trough theophylline concentrations; such patients may benefit from therapy with an extended-release preparation.See Warning/Precautions under Cautions and also see Interactions for information on risk factors for decreased theophylline clearance.Adults ≥16 years of age (weighing >45 kg) without risk factors for reduced theophylline clearanceInitially, 300 mg daily in divided doses; after 3 days, Adults ≥16 years of age with risk factors for reduced theophylline clearance, including patients >60 years of age and those in whom serum concentrations cannot be monitoredInitially, 300 mg daily in divided doses; after 3 days, Monitor serum theophylline concentrations at 24-hour intervals to adjust final dosage.Dosage reduction and/or serum theophylline concentration measurement is indicated whenever adverse effects are present, physiologic abnormalities that can reduce theophylline clearance occur (e.g., sustained fever), or a drug that interacts with theophylline is added or discontinued.

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