The fraction of bound methocarbamol was slightly decreased in the elderly versus younger volunteers (41 to 43% versus 46 to 50%, respectively).The clearance of methocarbamol in 8 renally-impaired patients on maintenance hemodialysis was reduced about 40% compared to 17 normal subjects, although the mean (± SD) elimination half-life in these two groups was similar (1.2 (± 0.6) versus 1.1 (± 0.3) hours, respectively).In 8 patients with cirrhosis secondary to alcohol abuse, the mean total clearance of methocarbamol was reduced approximately 70% compared to that obtained in 8 age- and weight-matched normal subjects. It is a sterile, pyrogen-free solution intended for intramuscular or intravenous administration.
Robaxin Injectable should be given to a pregnant woman only if clearly needed.Safe use of Robaxin Injectable has not been established with regard to possible adverse effects upon fetal development. Imipramine is sometimes used to treat bed-wetting in children ages 6 and older.
Overdose of methocarbamol is frequently in conjunction with alcohol or other CNS depressants and includes the following symptoms: nausea, drowsiness, blurred vision, hypotension, seizures, and coma. https://www.webmd.com/drugs/2/drug-9476/robaxin-injection/details Administer IV while in recumbent position.
The injections may be repeated at eight hour intervals, if necessary. Monitor closely for extravasation. Since Robaxin Injectable is hypertonic, vascular extravasation must be avoided. Available for Android and iOS devices.
Therefore, Robaxin Injectable should not be used in women who are or may become pregnant and particularly during early pregnancy unless in the judgment of the physician the potential benefits outweigh the possible hazards (see Methocarbamol and/or its metabolites are excreted in the milk of dogs; however, it is not known whether methocarbamol or its metabolites are excreted in human milk. Robaxin®/Robaxin 750® (methocarbamol) Tablets, USP. Imipramine may also be used for purposes not listed in this medication guide. Use injection with caution in patients with a history of seizures.
Therefore, methocarbamol should be used with caution in patients with myasthenia gravis receiving anticholinesterase agents.Methocarbamol may cause a color interference in certain screening tests for 5‑hydroxyindoleacetic acid (5-HIAA) using nitrosonaphthol reagent and in screening tests for urinary vanillylmandelic acid (VMA) using the Gitlow method.Long-term studies to evaluate the carcinogenic potential of methocarbamol have not been performed. Essentially all methocarbamol metabolites are eliminated in the urine. Keep the bottle tightly closed when not in use.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. It is a sterile, pyrogen-free solution intended for intramuscular or intravenous administration.Each mL contains: methocarbamol, USP 100 mg, polyethylene glycol 300, NF 0.5 mL, Water for Injection, USP q.s. Muscle Relaxants for Back Pain Are Soaring: Are They Safe? The usefulness of hemodialysis in managing overdose is unknown.For the relief of symptoms of moderate degree, one dose of 1 gram (one 10 mL vial) may be adequate. Select one or more newsletters to continue. There have been very rare reports of fetal and congenital abnormalities following in utero exposure to methocarbamol. Available for Android and iOS devices.
Small amounts of unchanged methocarbamol also are excreted in the urine.The mean (± SD) elimination half-life of methocarbamol in elderly healthy volunteers (mean (± SD) age, 69 (± 4) years) was slightly prolonged compared to a younger (mean (± SD) age, 53.3 (± 8.8) years), healthy population (1.5 (± 0.4) hours versus 1.1 (± 0.27) hours, respectively). It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.In healthy volunteers, the plasma clearance of methocarbamol ranges between 0.20 and 0.80 L/h/kg, the mean plasma elimination half-life ranges between 1 and 2 hours, and the plasma protein binding ranges between 46% and 50%.Methocarbamol is metabolized via dealkylation and hydroxylation. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties.
You may need to reduce your dose after the first 2 or 3 days of treatment. Tell any doctor who treats you that you are using Robaxin.Store at room temperature away from moisture and heat. Rate of injection should not exceed 3 mL per minute–i.e., one 10 mL vial in approximately three minutes. Robaxin injection is injected into a muscle or given as an infusion into a vein.
Sedative effects potentiated when used with other sedatives.
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