This sensitivity analysis indicates that the conclusions of the study would probably still apply in a real-life setting, even taking into account the difference between efficacy in a clinical trial compared to standard UK clinical practice.Multifactorial interventions that improve blood pressure, glycaemic control, lipid profiles and screening rates have demonstrated reductions in complications, improvements in other patient outcomes and were either cost saving or cost-effective in the management of type II diabetes.Both losartan and irbesartan have been demonstrated to be cost saving in other studies. Treatment leading to a slowing of progression to ESRD in diabetic patients could lead to considerable cost savings. Simply select your manager software from the list below and click on download. I-ADD study: assessment of efficacy and safety profile of irbesartan/amlodipine fixed-dose combination therapy compared with irbesartan monotherapy in hypertensive patients uncontrolled with irbesartan 150 mg monotherapy: a multicenter, phase III, prospective, randomized, open-label with blinded-end point evaluation study. Multicentre, randomised, double-blind, comparative pilot study.Methods. Palmer AJ et al. IRB=irbesartan; AML=amlodipine.Reduction in progression to DSC and ESRD with irbesartan led to projected improvements in undiscounted life expectancy (discounted life expectancy shown in brackets) due to delayed or avoided ESRD of 0.08 (0.07) years and 0.23 (0.21) years One-way sensitivity analysis of the total 10-year costs revealed that the parameter with the greatest single impact was the annual costs of dialysis. Find out about Lean Library If you have an individual subscription to this content, or if you have purchased this content through A modelling study performed in the UK setting for patients with type I diabetes and nephropathy demonstrated that treatment with the ACE inhibitor captopril (25 mg three times a day) would lead to discounted cost savings of £953 per patient over a 4-year period.In conclusion, this modelling study demonstrates that irbesartan therapy leads to a reduction in 10-year treatment costs of type II diabetic patients in the UK compared to amlodipine or standard antihypertensive therapy alone. Modelling and costing the consequences of using an ACE inhibitor to slow the progression of renal failure in type I diabetic patients. Discounting was performed in accordance with current National Institute for Clinical Excellence guidelines using rates of 6.0% per annum for future costs, and 1.5% for future clinical benefits.One-way sensitivity analysis was performed on total costs by varying each probability and cost parameter by±10% one at a time while holding all other parameters constant, so as to rank the order of their impact. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)The impact of ethnicity on response to antihypertensive therapyA comparison of the efficacy and safety of a beta-blocker, a calcium channel blocker, and a converting enzyme inhibitor in hypertensive blacksRegional and racial differences in response to antihypertensive medication use in a randomized controlled trial of men with hypertension in the United StatesThe relationships between dose and antihypertensive effect of four AT1-receptor blockersComparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertensionAn ambulatory blood pressure monitoring study of the comparative antihypertensive efficacy of two angiotensin II receptor antagonists, irbesartan and valsartanComparative efficacy of two angiotensin II receptor antagonists, irbesartan and losartan in mild-to-moderate hypertensionCOmparative Study of efficacy of Irbesartan/ hydrochlorothiazide with valsartan/hydrochlorothiazide using home blood pressure Monitoring in the treAtment of mild to moderate hypertension (COSIMA)Presented at the 24th Meeting of the French Society of Arterial HypertensionRenoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetesSAGE Publications Ltd, unless otherwise noted.
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