It diffuses readily into all body fluids (cerebrospinal, pleural and ascitic fluids), tissues, organs and excreta (saliva, sputum and feces). (Note: the criterion for a positive reaction to a skin test (in millimeters of induration) for each group is given in parenthesis):Additionally, in the absence of any of the above risk factors, persons under the age of 35 with a tuberculin skin test reaction of 10 mm or more are also appropriate candidates for preventive therapy if they are a member of any of the following high-incidence groups:Children who are less than 4 years old are candidates for isoniazid preventive therapy if they have greater than 10 mm induration from a PPD Mantoux tuberculin skin test.Finally, persons under the age of 35 who a) have none of the above risk factors (1 to 6); b) belong to none of the high-incidence groups; and c) have a tuberculin skin test reaction of 15 mm or more, are appropriate candidates for preventive therapy.The risk of hepatitis must be weighed against the risk of tuberculosis in positive tuberculin reactors over the age of 35. Isoniazid is slowly affected by exposure to air and light.Within 1 to 2 hours after oral administration, isoniazid produces peak blood levels which decline to 50 percent or less within 6 hours. The risk may also be increased during the post partum period. Danazol, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema and other conditions. These include any of the following: unexplained anorexia, nausea, vomiting, dark urine, icterus, rash, persistent paresthesias of the hands and feet, persistent fatigue, weakness or fever of greater than 3 days duration and/or abdominal tenderness, especially right upper quadrant discomfort.
Each tablet also contains as inactive ingredients: anhydrous lactose, calcium stearate, colloidal silicon dioxide, microcrystalline cellulose, and stearic acid. Psychotic re-actions and coordination difficultiesmay resultwithdisulfiram.Concurrentadmin-istration of pyridoxinemay prevent neuropathy.qrisk of hepatotoxicity with other hepatotoxicagentsincluding alcohol, acetaminophenand rifampin. From 50 to 70 percent of a dose of isoniazid is excreted in the urine in 24 hours.Isoniazid is metabolized primarily by acetylation and dehydrazination. Each tablet also contains as inactive ingredients: anhydrous lactose, calcium stearate, colloidal silicon dioxide, microcrystalline cellulose, and stearic acid.Isoniazid is chemically known as isonicotinyl hydrazine or isonicotinic acid hydrazide. Because isoniazid has some monoamine oxidase inhibiting activity, an interaction with tyramine-containing foods (cheese, red wine) may occur.
Severe and sometimes fatal hepatitis has been reported with isoniazid therapy and may occur even after many months of treatment. The risk of hepatitis is increased with daily consumption of alcohol. Thus, response to treatment often must be judged on the basis of clinical and radiographic findings.The use of adjunctive therapies such as surgery and corticosteroids is more commonly required in Extra pulmonary tuberculosis than in pulmonary disease. It is taken by mouth. Uses of Danazol: It is used to treat endometriosis. Approximately 50 percent of Blacks and Caucasians are “slow inactivators” and the rest are “rapid inactivators”; the majority of Eskimos and Orientals are “rapid inactivators.”The rate of acetylation does not significantly alter the effectiveness of isoniazid. You may need to take other TB medicines in combination with isoniazid. Usually, enzyme levels return to normal despite continuance of drug, but in some cases progressive liver dysfunction occurs. Strict adherence to the manufacturer’s instructions for sample processing and data interpretation is required for this assay.Isoniazid Tablets, USP are recommended for all forms of tuberculosis in which organisms are susceptible. If isoniazid therapy must be reinstituted, the drug should be given only after symptoms have cleared. Tyramine- and histamine-containing foods should be avoided in patients receiving isoniazid.
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