I'd hate to suddenly gain a lot! All three trials demonstrate that weight gain occurs primarily within the first 12 months of active treatment in a subset of patients. Significant baseline predictors for gaining more than 5 kg of weight after 12 months of follow-up were: being younger than 60 years old, smoking and mastectomy. Please enable it to take advantage of the complete set of features!
Hello and good morning I hope it's a good morning for u? 2016 Feb 27;387(10021):866-73. doi: 10.1016/S0140-6736(15)01129-0.
I'm quite strict now with my diet and don't over eat or snack much. Name must be less than 100 characters Registered office: 89 Albert Embankment, London SE1 7UQ.
2016 Feb 27;387(10021):849-56. doi: 10.1016/S0140-6736(15)01168-X. Epub 2015 Dec 11.Margolese RG, Cecchini RS, Julian TB, Ganz PA, Costantino JP, Vallow LA, Albain KS, Whitworth PW, Cianfrocca ME, Brufsky AM, Gross HM, Soori GS, Hopkins JO, Fehrenbacher L, Sturtz K, Wozniak TF, Seay TE, Mamounas EP, Wolmark N.Lancet. Breast Cancer Res Treat.
Epub 2008 Sep 1.Clin Breast Cancer. Hi glitzy gran I've been on letrozole now for 3 weeks I thought it was just being me being greedy but I'm exactly the same I wake up during the night so hungry and I am starting to notice the weight gain. Looks like I will just have to stick with the hunger pangs and buy bigger clothes :-( However I remind myself the Letrozole are doing a job!
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Some side effects of letrozole may occur that usually do not need medical attention. Epub 2018 Oct 6.Raghavendra A, Sinha AK, Valle-Goffin J, Shen Y, Tripathy D, Barcenas CH.Clin Breast Cancer. This site needs JavaScript to work properly. I'm no longer on Letrozole - long story but nothing to do with my cancer treatment. I'd also like to know that once we girls are through this 5-year nightmare does the weight gain start to decrease? I have been taking letrozole for about 5 weeks and I find after about an hour after eating a meal and during the night I am absolutely starving hungry!
I have put on a couple of pounds already. Epub 2015 Dec 11.Jenkins VA, Ambroisine LM, Atkins L, Cuzick J, Howell A, Fallowfield LJ.Lancet Oncol. I have also experienced hunger but didn't put it down to the tablets, maybe it was.... been on the new ones since Saturday so here's hoping an easier recovery :-) x JulieHi Yvonne, I also now have a sweet tooth which I didn't have before :-( Hi I've been on Letrozole for 16 months and have pur on over 2.5 stones in weight, I've got stiff joints - I laugh as i'm like the tinman when I get up in the morning and this is after sweating all night but this is the lesser of 2 evil's as I know I'm on a wonderful drug.Oh dear Ella I was hoping the side effects would 'improve' in time! Please support our emergency appeal.
Hi TigerEve It might be worth having a blood test for low thyroid as many of your symptoms are similar. Doesn’t matter which estrogen blocker we take, we gain weight! Weight gain is commonly reported by breast cancer patients on tamoxifen or aromatase inhibitors. Data on weight change in postmenopausal women from three large clinical trials investigating endocrine therapy for the treatment or prevention of breast cancer were analysed (ATAC, IBIS-I and IBIS-II). Has anyone else experienced this hunger? I took Anastrozole but had to switch to Letrozole. I had done a bit of research while taking it, I had a year of misery with stiff joints, hot flushes through the roof & feeling sluggish probably because of weight gain.
Besides that I too have developed a sweet tooth over the past 2 years, although I don't overeat (I never have). I've had no bad side effects yet but did notice I'd gained a pound.
In the IBIS-I study, mean weight change on tamoxifen was +0.1 kg (SD 0.1) compared with +0.3 kg (SD 0.1) in women taking the placebo (P = 0.3) between baseline and 12 months of follow-up. Also operating in Northern Ireland.
Oh, boy, can I relate! I weigh more now than ever in my life, and it’s frustrating. doi: 10.1016/j.clbc.2017.11.006.
Since weight gain may impact on outcome and compliance we have prospectively assessed the effects of these agents on weight change in three randomised trials for the treatment or prevention of breast cancer. 2018 Feb;18(1):e7-e13. These side effects may go away during treatment as …
Isle of Man company number 4694F. weight gain; white or brownish vaginal discharge; yellow eyes and skin; Side effects not requiring immediate medical attention. I lost a lot of weight through my cancer journey. Not sure if this is the Letrozole or just an age-thing as I am in my late fifties. Hi glitzygran I have been on letrozole for 18 months and the weight gain is horrendous, on the plus side it's doing it's job. Epub 2017 Nov 9.Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, Peto R, Pritchard KI, Bergh J, Dowsett M, Hayes DF; EBCTCG.N Engl J Med. Does anyone have any answer to this?
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