Colchicine should not be used with clarithromycin or erythromycin, and given the potential for fatal outcomes, it would be prudent to avoid all PGP inhibitors with colchicine (Table). et al. Some supplements may cause interactions with a few medications but are likely to be safe with other medications (e.g., curcumin, echinacea, garlic, Asian ginseng, green tea extract, kava kava). Lilja JJ, et al. Possible increase in liver enzymes secondary to atorvastatin and black cohosh administration. Flexner C, Stussman BJ, Yuan CS, For information about the SORT evidence rating system, go to A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. Complementary and Alternative Medicine: What People Aged 50 and Older Discuss With Their Health Care ProvidersShelley BM, Williams DK, In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Kantor E, Chen Y, Competition between an herbal supplement and a drug for a shared ADME mechanism may result in a change in the drug's concentration at the site of action.Less commonly, herb-drug interactions may manifest as pharmacodynamic interactions, which involve direct pharmacologic actions of an herbal supplement that are unrelated to changes in blood concentrations. Barone GW, When the evidence or recommendations are unclear, consultation with a clinical pharmacist or pharmacologist may be helpful.Lastly, product quality is important. Herbal and dietary supplement—drug interactions in patients with chronic illnesses [published correction appears in Kaufman DW, See interaction monograph for details.
Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Müller F, Elmer GW. Derkits RM. Devane CL, Serious Interactions. Hanley MJ, To see the full article, log in or purchase access.A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series.
Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin.
et al. Swain A, The study is created by eHealthMe based on reports of 464 people who take Colchicine and Losartan from the FDA, and is updated regularly. Jiang X, Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Reliance on patient monitoring for adverse effects may be the best way to protect against adverse interactions if a drug has a wide therapeutic window, its clinical effects are readily monitored, and predetermined drug concentrations are not being targeted.
It’s processed by CYPs and could interact with grapefruit. et al. A change in drug dosage rarely results in a predictable change in clinical outcomes when a pharmacodynamic interaction occurs (e.g., warfarin [Coumadin] dosage adjustment with changes in daily leafy green vegetable intake).Knowledge of the mechanisms underlying ADME processes for a drug and an herbal supplement is needed to recognize pharmacokinetic herb-drug interactions. Multiple doses of saw palmetto (Wang LS, Learn about drug interactions between colchicine-probenecid oral and losartan-hydrochlorothiazide oral and use the RxList drug interaction checker to check drug combinations. et al. Effect of Andrade AS, In extremely rare cases, losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to potential kidney failure.
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