Air travel. Nephron 1990; 55 Suppl. Effect of captopril on kidney function in insulin-dependent diabetic patients with nephropathy. 45: S121–4Lewis EJ, Hunsicker LG, Bain RP, et al.
Calcium regulating hormones. The effects of dietary protein restriction and blood pressure control on the progression of chronic renal disease. 58: S66–8Mimran A, Ribstein J, DuCailar G. Contrasting effect of anti-hypertensive treatment on the renal response to L-Arginine. First, reduction in blood pressure (BP) is a fundamental prerequisite common to all antihypertensive drugs. ScienceDaily. J Nephrol 1997; 10: 203–6Epstein M. Diabetes and hypertension: bad companions. 2002;62(2):339-85. doi: 10.2165/00003495-200262020-00009.Suzuki Y, Lopez-Franco O, Gomez-Garre D, Tejera N, Gomez-Guerrero C, Sugaya T, Bernal R, Blanco J, Ortega L, Egido J.Am J Pathol. "Since glycemic control was only modestly different between canagliflozin and glimepiride, our results suggest that potential kidney protective effects of canagliflozin may be unrelated to glycemic control," said Dr. Heerspink. increased risk of cardiovascular complications in hypertensive type 2 diabetic patients. 63: S67–70Gansevoort RT, de Zeeuw D, de Jong PE. 2008, 19: 151-57. Nephrol Dial Transplant 1996; 11 Suppl. Systemic and renal effects of chronic angiotensin converting enzyme inhibition with captopril in hypertensive diabetic patients. The exact definition of the level to which BP should be reduced remains to be established, although there is some evidence that BP should be reduced below 130/85 mm Hg in patients with diabetic … Long-term progression of chronic renal insufficiency in the AIPRI extension study. Am J Kidney Dis 1993; 21 Suppl. Influence of converting enzyme inhibition on glomerular filtration rate and proteinuria. Am J Kidney Dis.
10.1046/j.1365-2796.2003.01207.x.Couser WG, Nangaku M: Cellular and molecular biology of membranous nephropathy. BMJ 1994; 309: 833–7vanEssen GG, Apperloo AJ, Rensma PL, et al. Name must be less than 100 characters Outcome results of the fosinopril versus amlodipine cardiovascular events randomized trial (FACET) in patients with hypertension and NIDDM. Kidney Int 1996; 50: 684–92Apperloo AJ, de Zeeuw D, de Jong PE. Arch Int Med 1993; 153: 1749–59Zucchelli P, Zuccalà A. Efficacy of nifedipine to prevent systemic and renal vasoconstrictor effects of endothelin. J Hypertens 1996; 14 Suppl. In contrast to other members of the ARB class, the renoprotective effect of telmisartan is not confined to the management of diabetic nephropathy; slowing the progression of albuminuria has been demonstrated in the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGETThe ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGETIn this review, we place these results in the context of existing data on telmisartan in diabetic nephropathy, beginning with a review of renal and cardiovascular disease.Serum creatinine, a commonly used indicator of renal impairment, shows substantial inter-individual variability due to non-renal factors - mainly due to differences in muscle mass.
In patients with diabetic overt nephropathy, ACE inhibitors and nondihydropyridine calcium antagonists are particularly effective in reducing proteinuria and both drugs can slow the decline in glomerular filtration rate more successfully than other antihypertensive treatment.Available data in patients with nondiabetic nephropathies indicate that ACE inhibitors can be beneficial, principally in patients with significant proteinuria, in slowing the progression of renal failure. However, it is still unclear whether this beneficial effect of ACE inhibitors is particularly evident in patients with mild and/or more advanced renal failure and whether calcium antagonists possess a similar nephroprotective effect.Overall, data from clinical trials thus seem to indicate that ACE inhibitors and possibly calcium antagonists should be preferred in the treatment of patients with diabetic and nondiabetic nephropathies. 2004, 65: 2309-20.
Effect of antihypertensive therapy on the kidney in patients with diabetes: a meta-regression analysis. Hypertension 1997; 29: 641–50Hebert LA, Kusek JW, Greene T, et al. The Diab-Hycar Study.
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