Its mode of action is distinct from established antidiabetic medications and appears to include disease-modifying effects in patients with type 2 diabetes.Galvus (vildagliptin), in advanced-stage development as a treatment for patients with type 2 diabetes, has now received the thumbs up from regulators in Europe. Due to safety concerns, the approval of Galvus was further delayed by the FDA.In January 2008, Novartis said that the company might not refile for the approval of Galvus until it receives clarification on the kind of data required by the FDA for the drug approval.

Figure 2. © 2007  American Society of Health-System Pharmacists Mechanism of action of vildagliptin. Illustration by Marie Dauenheimer, CMI.Click the topic below to receive emails when new articles are available. Approval has also been granted for Eucreas, a single tablet formulation of Galvus (vildagliptin) and metformin.In March 2006, a new drug application for Galvus was accepted for review by the FDA. In February 2007, the FDA requested Novartis to conduct a new study to assess the safety and efficacy of Galvus in patients with impaired kidneys.Novartis submitted data based on this request in November 2007. Without the presence of vildagliptin, GLP-1 is rapidly inactivated and degraded by the enzyme dipeptidyl peptidase IV (DPP4); when vildagliptin is present, vildagliptin binds to DPP4, allowing GLP-1 to remain active. In preclinical studies, Galvus (vildagliptin) was found to have a beneficial effect on insulin secretion by increasing beta cell production and inhibiting programmed cell death (apoptosis).Subsequent clinical studies, in which vildagliptin was administered to patients with type 2 diabetes not previously treated with oral antidiabetic medications, showed that it increased the active forms of GLP-1 and GIP when compared with the placebo. Low price and best customer support! They bind to receptors on pancreatic beta cells stimulating the release of the hormone insulin, responsible for the regulation of blood sugar levels. Please see our Comments on Medscape are moderated and should be professional in tone and on topic. Following this development, the approval of Galvus in the US remains uncertain. This translated into improved beta cell function as measured by enhanced insulin secretion on glucose challenge.The drug’s ability to improve the functioning of insulin-producing cells in the pancreas, albeit in studies with small numbers of patients, suggests it may have disease-modifying potential in the treatment of type 2 diabetes.The World Health Organization (WHO) estimates that globally over 170 million people have diabetes. Novartis’ Galvus (vildagliptin) works by inhibiting DPP-IV, an enzyme that breaks down GLP-1.By delaying the degradation of GLP-1, vildagliptin extends the action of insulin while also suppressing the release of glucagon. Vildagliptin - Mode of Action James Edward Foley* Director Global Medical Affairs, Novartis Pharmaceuticals Corporation, 100 West Village Promenade, East Hanover , NJ 07936-1080, USA They bind to receptors on pancreatic beta cells stimulating the release of the hormone insulin, responsible for the regulation of blood sugar levels.GLP-1 also reduces the secretion of glugacon, a hormone produced by the pancreas that stimulates the liver to convert glycogen to glucose, thus increasing blood sugar levels. Commenting is limited to medical professionals. Levels of haemoglobin A1c (HbA1c), fasting plasma glucose, mean prandial glucose and peak prandial glucose were reduced to a significantly greater effect after 12 weeks of additional treatment with vildagliptin compared with continued therapy with metformin alone.Importantly, the results achieved at 12 weeks were sustained over a year, indicating that patients treated with vildagliptin can achieve good long-term glycaemic control. To comment please Comments on Medscape are moderated and should be professional in tone and on topic. In patients maintained on metformin alone, glycaemic control tended to deteriorate over time.Long-term treatment with Galvus (vildagliptin) appears well-tolerated as reflected by low rates of study discontinuation for adverse events in clinical trials. Illustration by Marie Dauenheimer, CMI.Am J Health Syst Pharm. In response to a meal, active glucagon-like peptide-1 (GLP-1) is secreted by the L cells of the intestines. If you log out, you will be required to enter your username and password the next time you visit. “Treatment with vildagliptin does not appear associated with weight gain, which is an important benefit for patients with type 2 diabetes.”“Novartis’ Galvus joins Merck’s Januvia as the second DPP-IV inhibitor to secure regulatory approval.”Inhibits action of DPP-IV, so delaying degradation of GLP-1

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