It may also help to decrease hallucinations (such as hearing /seeing things that are not there). 10 and the 25 mg capsules contain FD&C Green No. 1 Aluminum Lake, FD&C Blue No. It acts like an atypical but without the problems of weight gain, hyperglycemia, increased risk of stroke, sudden cardiac death, blood clots, and diabetes that the atypicals may cause. The possibility of occurrence of extrapyramidal symptoms and/or convulsive seizures should be kept in mind. Drowsiness, usually mild, may occur at the beginning of therapy or when dosage is increased. Loxapine is metabolized extensively and is excreted mainly in the first 24 hours. The incidence of sedation has been less than that of certain aliphatic phenothiazines and slightly more than the piperazine phenothiazines. It seems to me that if clozapine and loxapine are so similar (they both bind to serotonin and dopamine receptors), loxapine should be the first drug of choice for the treatment of psychotic symptoms. Loxapine administration to nursing women should be avoided if clinically possible.Safety and effectiveness of Loxapine in pediatric patients have not been established.Manifestations of adverse effects on the central nervous system, other than extrapyramidal effects, have been seen infrequently. Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. We traced the serum levels of total amoxapine (amoxapine plus 8-hydroxyamoxapine) in two treatment-resistant patients with psychotic-depression syndromes. As would be expected from the pharmacologic actions of the drug, the clinical findings may range from mild depression of the CNS and cardiovascular systems to profound hypotension, respiratory depression, and unconsciousness. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system (CNS) pathology.The management of NMS should include: 1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and medical monitoring, and 3) treatment of any concomitant serious medical problems for which specific treatments are available. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Loxapine capsules are administered, usually in divided doses, two to four times a day. For patients with diseases, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on long-term antipsychotic therapy.In clinical trial and postmarketing experience, events of leukopenia/neutropenia and agranulocytosis have been reported temporally related to antipsychotic agents.Possible risk factors for leukopenia/neutropenia include preexisting low white blood cell count (WBC) and history of drug induced leukopenia/neutropenia. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. Neuroleptic malignant syndrome (NMS) has been reported (see Neuromuscular (extrapyramidal) reactions during the administration of Loxapine have been reported frequently, often during the first few days of treatment. The symptoms are persistent and in some patients appear to be irreversible.
Increased pulse rates have been reported in the majority of patients receiving antipsychotic doses; transient hypotension has been reported. In the presence of severe hypotension requiring vasopressor therapy, the preferred drugs may be norepinephrine or angiotensin. Perinatal studies have shown renal papillary abnormalities in offspring of rats treated from mid-pregnancy with doses of 0.6 mg/kg and 1.8 mg/kg, doses which approximate the usual human dose but which are considerably below the maximum recommended human dose.The extent of the excretion of Loxapine or its metabolites in human milk is not known. Seizures have been reported in patients receiving Loxapine at antipsychotic dose levels, and may occur in epileptic patients even with maintenance of routine anticonvulsant drug therapy.Loxapine has an antiemetic effect in animals. Please enable it to take advantage of the complete set of features! In addition, emesis should be avoided because of the possibility of aspiration of vomitus.
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