NDMA is not expected to cause harm when ingested at low levels. NDMA is a cancer-causing contaminant called N-Nitrosodimethylamine.
OTTAWA – Health Canada is aware that some metformin products available outside Canada have been found to contain a nitrosamine impurity, N-nitrosodimethylamine (NDMA), above the acceptable limit. View Article PubMed/NCBI Google Scholar 10. In December 2019 Health Canada announced that it is aware that some Metformin …
Health Canada states that people are exposed to low levels of nitrosamines through a variety of foods, including smoked and cured meats, dairy products, and vegetables, as well as through drinking water, and air pollution. (Wikimedia Commons photo)An article about the possible link between the prescription drug Metformin and cancer is raising concerns for diabetes sufferers.Metformin is a drug widely used in Canada to treat Type 2 diabetes. Health Canada is looking into whether some metformin, a drug used to treat Type 2 diabetes, contains a cancer-causing impurity after other countries found problems with the drug. A person taking a drug that contains NDMA at or below the acceptable level every day for 70 years is not expected to have an increased risk of cancer. Should any additional recalls be necessary, Health Canada will update the table below and inform Canadians. On Saturday, Health Canada announced the recall was in effect for Apotex’s prescription metformin drug APO-METFORMIN ER (extended release) 500-milligram tablets. Metformin is the most commonly prescribed treatment for type 2 diabetes and has consistently shown anti-cancer benefits in research studies. Das Mittel schützt die DNA vor Schäden durch reaktive Sauerstoffverbindungen. Health Canada has been working to address the issue of NDMA and other nitrosamine impurities found in certain medications since the summer of 2018.
Prescription medication is shown in this file photo. Health Canada is also working closely with international regulatory partners to inform its assessment of the issue and to determine whether any Metformin product in Canada is affected.“As a result of its recent product analysis, Ranbaxy Pharmaceuticals Canada Inc. is recalling six lots of its prescription RAN-Metformin drug from the Canadian market due to findings of NDMA. NDMA is classified as a probable human carcinogen.“We are all exposed to low levels of nitrosamines through a variety of foods (such as smoked and cured meats, dairy products and vegetables), drinking water and air pollution,” says the Health Canada report.Back in December Health Canada stated it is not aware of any Metformin products in Canada containing NDMA above acceptable levels. As a precautionary measure, the company is also recalling eight other lots because levels of NDMA in those products may increase over time. There are also alternative metformin products on the Canadian market manufactured by other companies. Metformin, a biguanide derived from the French lilac, has become the preferred first-line therapy for the treatment of type 2 diabetes (1). What to do:You should not stop taking your metformin drug without first discussing options with your health care provider. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. “The risks from not having adequate diabetes treatment outweigh any possible effects of exposure to the levels of nitrosamines found in the recalled Apotex metformin products,” the agency said in a statement. Company test results showed one of the lots (PY7174) contains a nitrosamine impurity called N-nitrosodimethylamine (NDMA) that increased over time to a level above the acceptable limit.
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