Neuro advised to wean him off both and put him on Zonisamide. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Jack is having 3-6 cluster seizures every two weeks and is on PB & KBr both of which are in the high theraputic range. I noticed this post and was hoping those who have their pups on Zonisamide might respond back and update us as to how they are all doing on this drug. I truly believe they enhanced her last few years, and it's my passion to spread the word through this website. Does this mean that the med is likely working? My epileptologist is weaning me off Lamictal and I have been started on zonisamide, the generic Zonegran.

As with most anticonvulsant drugs, Zonisamide can cause drowsiness, incoordination (loss of muscle control), and a depressed appetite in dogs. Monitor your pet’s reaction to the supplement.
While Zonisamide appears to be relatively safe for dogs, is effective in controlling seizures, and is well-tolerated, we lack long-term studies demonstrating safety and effectiveness. Introduce your pet to CBD slowly.

If so, you may have heard about CBD and how some pet owners use it to gradually replace their pet’s prescription drugs.In this article I share my top tips on how to wean your pet off their medications using CBD.While CBD is a natural and safe compound, it can interact with other drugs.This is because CBD affects the activity of specific liver enzymes that play a big role in metabolizing a wide variety of drugs.These enzymes are known as cytochrome P450 and help breakdown around 60% of all the medications currently on the market.This includes NSAIDs, anticonvulsants, antidepressants, and much more.Studies show that CBD can inhibit the activity of these enzymes, hence slowing down the rate at which the liver processes and breaks down other medications.Ultimately, this means the medications stay in the body for longer, possibly having prolonged effects.The rate by which CBD affects the activity of P450 liver enzymes can vary depending on dosage as well as the presence of any other medications in the body.Some of the medications CBD can interact with include steroids, NSAIDs, anesthetics, allergy medications, anticonvulsants, and anti-anxiety medications.I also talk about the safety of CBD on its own in the above report, which is always important to consider when starting your dog on a new supplement.In fact, some studies suggest that cannabinoids can help increase the efficacy of some medications like painkillers, for example.You can read more about the synergism of cannabinoids with other pain medications in this Now, the fact that CBD can synergize with other drugs can be both positive and problematic.This leads researchers to believe that cannabinoids like CBD could help lower opioid doses in patients and help them slowly decrease their dependence on these drugs.At the same, the fact that cannabinoids interact with other drugs could prove problematic.As I mentioned earlier, CBD can affect liver enzymes and affect the rate at which the liver processes other drugs.This could increase the chances of some medications causing side effects and possibly affect the dose at which these other medications should be taken, seeing as they’ll stay in the body for longer.There are even fewer studies that focus particularly on veterinary drugs.Before I move on to show you how to wean your dog off their regular medications, I want to take a closer look at how CBD can affect drug dosage.This is really important, seeing as some medications, like chemotherapy drugs and anticonvulsants, are often administered at very specific doses.This dose should be strong enough to be as effective as possible, yet small enough to minimize toxicity.The drugs used in chemotherapy are, like many other medications, metabolized by cytochrome P450 enzymes in the liver.Therefore, using CBD together with chemotherapy could be risky because it may cause higher blood concentrations of the chemotherapy drugs.This means a normally safe dose of chemotherapy could, potentially, become unsafe when used together with CBD.Or that’s what experimental study results tell us, at least.These patients find that CBD helps them maintain a healthy appetite, fight the fatigue and lethargy that chemotherapy often produces, manage pain, and much more.The CBD only seemed to enhance Rosie’s treatment and improve her condition.As Rosie’s cancer progressed, she lived in constant pain, became lethargic, and suffered from a failing appetite.As a pet owner, I’m sure you can imagine how devastating it was to see Rosie’s condition so rapidly deteriorate right in front of my eyes.When I heard about the benefits of CBD for people and pets with cancer, I was obviously super intrigued.Nonetheless, I didn’t rush into the treatment and spent a lot of time reading up on CBD and how it worked.I also spent a lot of time discussing the treatment with my vet before finally deciding to give it a shot.And I’m so glad I did because the results were incredible.CBD helped Rosie with her pain, increased her energy levels, and helped her regain her appetite.Within just a week of starting the treatment, both my vet and I were blown away by Rosie’s improvement.Note that this is just my experience, and you shouldn’t take my word as gospel.If you’re thinking about using CBD with your pet, talk to your vet about it and the effect it may have on the medications your pet is currently taking.The answer to this obviously depends a lot on your pet’s condition and the medication they are taking.If you decide that CBD could be beneficial for your dog, next you’ll need to look at what supplement or medications they are currently taking.Talk to your vet about how these drugs are processed in the body and whether, given CBD’s effect on liver enzymes, there is a possibility of an interaction.Also look for the drugs your dog is taking on the P450 Flockhart Drug Interactions Chart.If you can’t find your dogs meds on this list, still talk to your vet before you decide to move ahead with CBD.Again, whether this is feasible will depend on your dog’s condition, as most serious conditions cannot go untreated for very long.If a drug interaction isn’t possible, you may want to start your pet on CBD alongside their regular medicines.Then, you can potentially start to wean your dog off their other drugs gradually.There are a number of things you can do to make your pet’s transition to CBD as smooth as possible.Here are some tips on using CBD with your dog and weaning them off their original medication:Before you do anything, consult your vet about the possibility of a drug interaction.

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