Astedt B, Jeppsson S, Pandolfi M "Fibrinolytic activity of veins during use of depot medroxyprogesterone acetate as a contraceptive." When suggestions are available use up and down arrows to review and ENTER to select. Each injection prevents ovulation and provides contraception for at least 12 weeks (+/- 5 days). Herbal preparations containing St John's wort (Aminoglutethimide has been reported to decrease plasma levels of some progestogens.Concurrent administration of ciclosporin and MPA has been reported to lead to increased plasma ciclosporin levels and/or decreased plasma MPA levels.Interactions with oral anti-coagulants have been reported rarely, but causality has not been established.When used in combination with cytotoxic drugs, it is possible that progestogens may reduce the haematological toxicity of chemotherapy.Special care should be taken when progestogens are administered with other drugs which also cause fluid retention, such as NSAIDs and vasodilators.Medroxyprogesterone acetate (MPA) is metabolized in-vitro primarily by hydroxylation via the CYP3A4. • Diabetes (a decrease in glucose tolerance has been observed in some patients).The pathologist (laboratory) should be informed of the patient's use of medroxyprogesterone acetate if endometrial or endocervical tissue is submitted for examination.The physician/laboratory should be informed that medroxyprogesterone acetate may decrease the levels of the following endocrine biomarkers: initially sterile, any multi-dose use of vials may lead to contamination unless Mukherjea M, Mukherjee P, Biswas R "Long-term contraception with Depo-Provera: a clinical evaluation."

2.2 Dosage in Patients with PMDD. Patients should be advised not to drive or operate machinery if affected. Kaunitz AM "Long-acting injectable contraception with depot medroxyprogesterone acetate." Task Force on Long-Acting Systemic Agents for Fertility Regulation." strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, The results of certain laboratory tests may be affected by the use of Depo-Provera. difficulty in predicting the time of withdrawal bleeding following injection, Revised: Apr 2017A statistically significant association has been It is recommended that the doctor uses these leaflets to aid counselling of the patient before giving the injection of Depo-Provera. depo-subQ provera 104 (medroxyPROGESTERone (medroxyprogesterone))." At the time of the final DMPA injection, BMD % changes from baseline in this cohort were -2.7%, -4.1% and -3.9% at the spine, total hip and femoral neck, respectively. Doses should be given by deep intramuscular injection. DEPO-PROVERA CI (medroxyprogesterone acetate) injectable suspension, for intramuscular use . Women should be counselled that Depo-Provera does not protect against sexually transmitted infections (STIs) including HIV infection (AIDS). The WHO Collaborative Study of Neoplasia and Steroid Contraceptives." Am J Med 113 (2002): 543-825. Specific drug-drug interaction studies evaluating the clinical effects with CYP3A4 inducers or inhibitors on MPA have not been conducted and therefore the clinical effects … Medroxyprogesterone systemic 10 mg (b 555 779) We comply with the HONcode standard for trustworthy health information - • Chronic use of drugs that can reduce bone mass, e.g. PVC/aluminium strip containing 30, 60 or 100 tablets.To bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. The SPC has been updated as follows: Update to Section 4.4 of the medroxyprogesterone acetate SmPCs to include new information recently added to the Company Core Data Sheet concerning use of progestogen containing injectable contraceptives like medroxyprogesterone acetate suspension for injection, and sexually transmitted … Women should be advised to contact their physician in case of mood changes and depressive symptoms, including shortly after initiating the treatment.History or emergence of the following conditions require careful consideration and appropriate investigation: migraine or unusually severe headaches, acute visual disturbances of any kind, pathological changes in liver function and hormone levels. WARNING: LOSS OF BONE MINERAL DENSITY See full prescribing information for complete boxed warning. It is unknown if use of DMPA-IM by younger women will reduce peak bone mass and increase the risk for fracture in later life i.e. However, it has been demonstrated that this drug, at least at high doses, can produce a hypercoagulable state. Lavecchia C "Depot-medroxyprogesterone acetate, other injectable contraceptives, and cervical neoplasia."

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