A subset (about 7%) of the population is devoid of CYP2D6 activity. The adverse events are reported regardless of causality.A 27-month-old child who ingested 5 to 7 tolterodine tartrate tablets 2 mg was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth.
pyloric stenosis Multiple oral total daily doses of immediate release 4 mg (therapeutic) and 8 mg (supratherapeutic) tolterodine have been shown to prolong the QTc interval (see section 5.1).
• Mydriasis: treat with pilocarpine eye drops and/or place patient in dark room An increase in QT interval was observed at a total daily dose of 8 mg immediate release tolterodine (twice the recommended daily dose of the immediate release formulation and equivalent to three times the peak exposure of the prolonged release capsule formulation) administered over four days. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Pack sizes: Tolterodine Tartrate tablets are available in blisters of 10, 20, 28, 30, 56, 60 & 100 tablets . Impaired liver function: About 2-fold higher exposure of unbound tolterodine and the 5-hydroxymethyl metabolite is found in subjects with liver cirrhosis (see sections 4.2 and 4.4). If it is near the time of the next dose, skip the missed dose. Therefore, Tolterodine Tartrate is not recommended for children.- Hypersensitivity to the active substance or to any of the excipients listed in section 6.1 Tolterodine shall be used with caution in patients with - Significant bladder outlet obstruction at risk of urinary retention - Gastrointestinal obstructive disorders, e.g. No increase in tumors was found in either mice or rats.No mutagenic effects of tolterodine were detected in a battery ofIn female mice treated for 2 weeks before mating and during gestation with 20 mg/kg/day (corresponding to AUC value of about 500 µg∙h/L), neither effects on reproductive performance or fertility were seen. Further metabolism leads to formation of the 5-carboxylic acid and N-dealkylated 5-carboxylic acid metabolites, which account for 51% ± 14% and 29% ± 6.3% of the metabolites recovered in the urine, respectively. The most severe adverse events observed were accommodation disturbances and micturition difficulties. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.This survey is being conducted by the WebMD marketing sciences department.All information will be used in a manner consistent with the WebMD See below for a comprehensive list of adverse effects.
For patients with significantly reduced hepatic or renal function or who are currently taking drugs that are potent inhibitors of CYP3A4, the recommended dose of Tolterodine Tartrate Tablets is 1 mg twice daily (see Overactive bladder happens when you cannot control your bladder muscle.
and Tolterodine Tartrate Tablets 2 mg (White, round, biconvex, film coated tablets engraved with “P 2” on one side & plain on the other side.)
The systemic clearance of tolterodine in extensive metabolisers is about 30 L/h. Unbound concentrations of tolterodine average 3.7% ± 0.13% over the concentration range achieved in clinical studies. The potential risk for humans is unknown.
Your condition will not improve any faster and your risk of serious side effects may be increased.Tell your doctor if your condition persists or worsens.Tell your doctor right away if you have any serious side effects, including: Get medical help right away if you have any very serious side effects, including: fast/slow/irregular heartbeat, severe dizziness, This is not a complete list of possible side effects. Headaches were also reported very commonly and occurred in 10.1% of patients treated with Tolterodine Tartrate tablets and in 7.4% of placebo treated patients. Two paediatric phase 3 randomised, placebo-controlled, double-blind 12 week studies were conducted using tolterodine extended release capsules. This medication is used to treat an overactive bladder. Tolterodine produced embryo death and malformations at plasma exposures (C In rabbits, no malformative effect was seen, but the studies were conducted at 20 or 3 times higher plasma exposure (CTolterodine, as well as its active human metabolites prolong action potential duration (90% repolarisation) in canine purkinje fibres (14 - 75 times therapeutic levels) and block the K+-current in cloned human ether-a-go-go-related gene (hERG) channels (0.5 – 26.1 times therapeutic levels).
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